University of Florida Health| Cancer Center
The scientific objectives of the MOO program are to elucidate the deregulated genetic and epigenetic events that drive tumor initiation and progression and develop new cancer targeting strategies. The research aims focus on identifying and characterizing genetic and epigenetic alterations, elucidating the role of noncoding RNAs in cancer, studying oncogenic mechanisms of DNA tumor viruses,…| Cancer Center
The catchment area is characterized by disproportionately higher cancer incidence and mortality rates than other regions in Florida. These disparities are evident in medically underserved populations, which include rural populations (16 out of 23 counties are rural), more than a quarter of racial/ethnic minority residents (26% underrepresented minorities, 16% of which are non-Hispanic Black and…| Cancer Center
This research is done by engaging key cancer pathways and identifying and developing novel biomarkers, assays and methods for rapid agent selection and clinical translation as part of precision oncology approaches. The program engages members of all four UF Health Cancer Center programs. It is implemented by disease group-focused mini-retreats, program meetings and IIT Think Tank (i2T3)-mediated structured facilitation of the translation of discoveries ranging from high-throughpu...| Cancer Center
The program develops and translates immunotherapy modalities, such as RNA-based vaccines, adoptive cellular therapies, genetically modified T cells and microbiome-based therapy, into first-in-human studies. The Comparative Oncology Initiative has allowed IOM investigators to validate new technologies in pet dog trials while a cadre of clinical trialists move these and other UF findings into human application.…| Cancer Center