Here, in a multi-ancestry genome-wide association study meta-analysis of kidney cancer (29,020 cases and 835,670 controls), we identified 63 susceptibility regions (50 novel) containing 108 independent risk loci. In analyses stratified by subtype, 52 regions (78 loci) were associated with clear cell …| PubMed
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. Some studies of highly-exposed individuals have suggested an association between PFAS and prostate cancer, but evidence from population-based studies is limited. …| PubMed
These findings are, to the best of our knowledge, the first cohort evidence relating solvent exposure levels among dry cleaners to elevated risks of selected cancers and heart disease. Additional studies employing solvent-specific exposure assessment are needed to clarify cancer risks associated wit …| PubMed
Differences in Tumor VHL Mutation and Hypoxia-inducible Factor 2α Expression Between African American and White Patients with Clear Cell Renal Cell Carcinoma| PubMed
Our findings offer additional support for an association between high levels of exposure to TCE and increased risk of NHL. However, we cannot rule out the possibility of confounding from other chlorinated solvents used for vapor degreasing and note that our exposure assessment methods have not been …| PubMed
Dr. Purdue is an internationally recognized expert in the study of cancer associations with occupational and environmental exposures to chlorinated solvents, per- and polyfluoroalkyl substances (PFAS) and other agents, and the etiology of kidney cancer.| dceg.cancer.gov
A listing of principal investigators in the Occupational and Environmental Epidemiology Branch (OEEB). Learn about their research interests.| dceg.cancer.gov
Dr. Mark Purdue and colleagues found that higher levels of PFOS, a specific PFAS, in blood collected from U.S. Air Force servicemen was associated with higher risk of developing testicular cancer.| dceg.cancer.gov