The highly pathogenic avian influenza virus (HPAIV) H5N1 clade 2.3.4.4b has rapidly disseminated globally, with mammalian infections reported in multiple species. Recent evidence of mammal-to-mammal transmission has heightened concerns about the virus’s potential adaptation to mammals. The polymerase basic 2 (PB2) protein E627K mutation appears to be of key importance for mammalian adaptation. We isolated an HPAI H5N1 clade 2.3.4.4b virus from wild birds in Korea with 96% E and 4% K at amin...| BioMed Central
South Korea combines three bird flu viruses into a single engineered mutant, increasing viral stability, altering host targeting, and enhancing human cell entry.| jonfleetwood.substack.com
Gov't has been funding gain-of-function on bird flu viruses, like it did to cause the COVID-19 pandemic—now it's spending half a billion dollars on coming influenza pandemic "solution."| jonfleetwood.substack.com