The same technology that enables targeted immunotherapy for cancer could be used to tackle Alzheimer’s
Proof-of-concept study shows CAR cells can detect both tau tangles and various forms of amyloid plaques| BUCK
Proof-of-concept study shows CAR cells can detect both tau tangles and various forms of amyloid plaques| BUCK
Background The lack of a definitive cure for Alzheimer's disease (AD) is fueling the search for innovative therapeutic strategies. Having revolutionized cancer immunotherapy, immune cell engineering with chimeric antigen receptors (CAR) is being explored to target AD. Whether CARs can recognize distinct amyloid-β (Aβ) species and tau neurofibrillary tangles (NFTs)—hallmark pathologies of AD—remains unclear. Methods To investigate this, we engineered a series of CARs using single-chain f...| BioMed Central
Researchers have found that when used on monkeys, an experimental drug slowed the process that leads the tau protein to aggregate into neuron-damaging tangles commonly seen in Alzheimer’s disease and improved the animals’ cognitive functioning. The next step is to develop a drug that can be used in…| New Atlas
A new form of immunotherapy helps immune cells “armor” themselves against exhaustion by releasing their own medicine to keep them going in the fight against cancer. In a small ongoing trial, 100% of patients have achieved complete remission, and the new method is faster and cheaper to produce than…| New Atlas
T cells are a type of white blood cell called lymphocytes that keep your immune system strong. Learn more about how T cells protect you from germs.| Cleveland Clinic
It wasn't that long ago that the only way to test for Alzheimer's disease was to perform an autopsy on someone who had been suffering from dementia to look for the telltale tangles of tau and amyloid proteins in the brain. While these tangles are not necessarily the cause of Alzheimer's disease,…| New Atlas
