A technology designed to preserve synapses across the whole brain of a large mammal is successfulUsing a combination of ultrafast glutaraldehyde fixation and very low temperature storage, researchers have demonstrated for the first-time ever a way to preserve a brain’s connectome (the 150 trillion synaptic connections presumed to encode all of a person’s knowledge) for centuries-long storage in a large mammal. This laboratory demonstration clears the way to develop Aldehyde-Stabilized Cry...| The Brain Preservation Foundation
"We're not just grieving the dead. We're grieving our own failure of imagination. And that's a grief our psychological frameworks aren't equipped to handle."| preservinghope.substack.com
Despite the last decade’s development of optogenetic methods for artificially manipulating engrams, and subsequent claims that there is a consensus that memories are stored in ensembles of synaptic connections, it remains unclear to what degree there truly is unanimity within the neuroscientific community about the neurophysiological basis of long-term memory. We surveyed 312 neuroscientists, comprising one cohort of experts on engram research and another of general neuroscientists, to asse...| journals.plos.org