This study analyzes the impact of diseases of despair on mortality within the Appalachian Region, focusing on mortality from three main causes: alcohol, prescription drug, and illegal drug overdose; suicide; and alcoholic liver disease/cirrhosis of the liver. It includes data through 2023 and serves as an update to previous ARC reports exploring the same issues.| Appalachian Regional Commission
ARC's INSPIRE Initiative addresses the substance use disorder (SUD) crisis in Appalachia by creating or expanding recovery ecosystems that will lead to workforce entry or re-entry.| Appalachian Regional Commission