Proof-of-concept study shows CAR cells can detect both tau tangles and various forms of amyloid plaques| BUCK
Background The lack of a definitive cure for Alzheimer's disease (AD) is fueling the search for innovative therapeutic strategies. Having revolutionized cancer immunotherapy, immune cell engineering with chimeric antigen receptors (CAR) is being explored to target AD. Whether CARs can recognize distinct amyloid-β (Aβ) species and tau neurofibrillary tangles (NFTs)—hallmark pathologies of AD—remains unclear. Methods To investigate this, we engineered a series of CARs using single-chain f...| BioMed Central
Taking inspiration from the CAR T-cell technology used to provide personalized cancer treatments, researchers have conducted a proof-of-concept study showing how similar compounds can precisely target protein tangles and plaques in the brain.| New Atlas