Symptoms vary depending on the individual, but they may include jaundice, tiredness, and painful swelling of the hands and feet. Serious symptoms needing medical attention include serious anemia, fever, acute chest syndrome, stroke, pain crises, and prolonged erections. Some symptoms are linked with other medical and social factors.| NHLBI, NIH
Sickle cell disease is an inherited blood disorder that affects hemoglobin, the protein that carries oxygen through the body. Misshapen red blood cells can block blood flow causing lifelong health problems. The only cure is a blood and bone marrow transplant, but treatments are available to manage the condition.| NHLBI, NIH