Background From 1918 to 1920, the largest influenza A virus (IAV) pandemic known to date spread globally causing between 20 to 100 million deaths. Historical records have captured critical aspects of the disease dynamics, such as the occurrence and severity of the pandemic waves. Yet, other important pieces of information such as the mutations that allowed the virus to adapt to its new host can only be obtained from IAV genomes. The analysis of specimens collected during the pandemic and stil...| BioMed Central
The preserved lung of an 18-year-old Swiss man has been used to create the full genome of the 1918 "Spanish flu," the first complete influenza A genome with a precise date from Europe. It offers new insights into the deadly pandemic that claimed the lives of up to 100 million people.| New Atlas