TL;DR: A lot of drugs try to mimic the benefits of ketogenic diets, and Retatrutide might be the closest yet. Nutritional Ketosis Mimetics I've long been interested in pharmacalogical interventions that attempt to do what a ketogenic diet does (and amused or at least bemused by the| Mostly Fat
A brief summary and elaboration of a point from a paper I recently published on energy signals on ketogenic diets (with special reference to effects on sleep). From what I have studied, satiety appears to be a consequence of the recovery of metabolic rate to baseline levels[1]. After a| Mostly Fat
This post is hosted on a permissionless platform using private cryptocurrency (Zcash) to allow micropayment donations and anonymity. Follow the link below to read the rest. An enduring mystery known to the low carb and Paleo spheres is how a very low fat, very high carb diet such as the| Mostly Fat
Beyond urinary ketones Several years ago I wrote about a common complaint to do with measuring urine ketones: sometimes they stop registering even when someone is on a strict low carb diet. This typically seems to happen when ketosis is mild — the strips just aren't sensitive enough,| Mostly Fat
Glycolysis breaks down glucose into pyruvate, producing ATP and NADH. Learn its steps, regulation, significance, and clinical relevance. The post Glycolysis – Definition, Steps, Regulation, and Significance appeared first on Science Notes and Projects.| Science Notes and Projects
Carolina Covenant scholar Melia Grady has led student government and completed pharmacy internships at Howard and Rutgers. The post Junior college jump-started transfer student’s experience appeared first on College of Arts and Sciences.| College of Arts and Sciences
Elsevier is going all in on AI and data. The latest release is an AI-powered search engine for its chemistry database, Reaxys.| Research & Development World
In a surprising twist, UNC scientists discovered that SETD2, a tumor suppressor best known for modifying DNA-packaging proteins, also preserves nuclear structure during cell division—a hidden role that may explain its tumor-suppressive effects in cancer. Continue reading| Newsroom
Digestive enzymes break down food into nutrients. Learn their types, functions, and importance in human and animal digestion.| Science Notes and Projects
The findings by Johns Hopkins researchers show the potential of AI to dramatically increase the speed of scientific discovery| The Hub
Proteins and RNA degrade at rates that render their spontaneous formation under natural, undirected conditions highly implausible.| Evolution News and Science Today
OK so here’s a different way of illustrating the Calvin Cycle, the light-independent sequence of reactions in photosynthesis. There are no molecular representations, no long chemical names. Instead, this cycle shows the number of carbon atoms in the input, output and cycle intermediates, together with their average oxidation states and the number of molecules present. […]| carnotcycle
Did you know that when flamingos are born, they are grey and their feathers are naturally white? Then… why do they display that pinkish colour? And hydrangeas, why do they show different colours? What do flamingos and hydrangeas have in common? And about the leaves of a tree…why do they change colour during the year? … Continue reading "Flamingos, hydrangeas, leaves and eggs" The post Flamingos, hydrangeas, leaves and eggs appeared first on One-pot Science.| One-pot Science
Changing the subject from my last post, it’s time to talk about DNA and the recent discoveries related to it. Let’s start with the most simple question. What is DNA? Deoxyribonucleic acid (DNA) is the biomolecule that encodes the genetic information of cellular organisms. It is composed of four molecules called nucleotides, which are represented with … Continue reading "DNA: much more than the molecule of life (I)" The post DNA: much more than the molecule of life (I) appeared first on...| One-pot Science
What is glucose 6-phosphate and how is it produced in bacterial and animal cells? What are its metabolic fates in the cell?| Tuscany Diet
Substrate-level phosphorylation is defined as the production of ATP or GTP following the transfer of a phosphate group from a substrate to ADP or GDP.[2] The energy released from the cleavage of a high-energy bond of the substrate facilitates the formation of the phosphoanhydride bond.[1] Part of this energy drives the reaction toward nucleotide triphosphate … Continue reading Substrate-level phosphorylation: what it is, examples, and functions→ The post Substrate-level phosphorylation: w...| Tuscany Diet
What are ketogenic amino acids, and why can't they be used for glucose synthesis? What role do they play during prolonged fasting?| Tuscany Diet
Folic acid (FA) is a synthetic form of folate or in other words vitamin B9. FA is the first and most popular supplement that a pregnant woman gets prescribed in order to avoid neural tube defects i…| Critical Check
Glucogenic amino acids are defined as amino acids whose carbon skeletons can be fully or partially catabolized into precursors for glucose synthesis or gluconeogenesis, hence the name.[2] Amino acids are the building blocks of proteins. When their pool meets the cellular needs for protein synthesis, since there are no amino acid stores in the body … Continue reading Glucogenic amino acids: definition, list, and role in prolonged fasting→ The post Glucogenic amino acids: definition, list, ...| Tuscany Diet
What is 2,3-bisphosphoglycerate? How is it produced? How does it affect the hemoglobin-oxygen bond? What factors influence its concentration?| Tuscany Diet
"Discovering new medicines is challenging work that requires the expertise of many. There are real synergies for our scientists and students as we build collaboration among departments," said Matthew Disney, Ph.D., chair of The Wertheim UF Scripps chemistry department.| wertheim.scripps.ufl.edu
Children born with a damaged gene needed for healthy brain development, SYNGAP1, experience seizures, sensory processing disorders, difficulty speaking, intellectual disability, and autism-like behaviors. It’s a condition without any treatments, one that’s hard both on parents and children, said Gavin Rumbaugh, Ph.D., a neuroscientist at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation &…| wertheim.scripps.ufl.edu
What is the Rapoport-Luebering shunt, and where does it occur? What reactions are involved? What are its energy cost and main product?| Tuscany Diet
CONTENT: INTRODUCTION (1) DNA ISOLATION (2) PCR (3.1) GEL ELECTROPHORESIS (3.2) BIOANALYZER – DNA CHIP (4) DNA PATERNITY REPORT CRITICAL REVIEW: DNA THEORY DNA THEORY – CRITICAL CHECKPO…| Critical Check
by Mia Breeze This paper looks at how Harold Hillman’s critique of the living cell impacts our current understanding of deoxyribonucleic acid (DNA), genetics, viruses, genetically modified organism…| Critical Check
The existence of DNA, its structure and its role are taught to us as facts; recognized and approved by all scientific establishments. But what if I told you that DNA started as a concept. Not DNA i…| Critical Check
The drug discovery process is the crucial first step in bringing a biopharmaceutical drug to the patients who need it.| ChemTalk
“No paper — I would wager quite heavily that a large percentage, probably over 90% of papers in the public domain, have errors in them. Whether or not they be known, I would suggest th…| For Better Science
Pyruvic acid: definition and structure. Synthesis in the cytosol and mitochondria. Use for energetic, biosynthetic and anaplerotic purpouses.| Tuscany Diet
Lactate dehydrogenase: genes, structure and active site. Regulation by pyruvate and lactate. Tissue distribution, and role in metabolism.| Tuscany Diet
What are keto acids? What is their chemical structure? How are they produced and what functions do they perform in the cell?| Tuscany Diet