Janice Pogue Lecture in Biostatistics, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada 2024-12-06 Slides| Statistical Thinking
Background Consider the problem of comparing two treatments by doing squential analyses by avoiding putting too much faith into a fixed sample size design. As shown here the lowest expected sample size will result from looking at the developing data as often as possible in a Bayesian design. The Bayesian approach computes probabilities about unknowns, e.g., the treatment effect, and one can update the current evidence base as often as desired, knowing that the current information has made pre...| Statistical Thinking