Background As explained here, the power for a group comparison can be greatly increased over that provided by a binary endpoint, with greater increase when an ordinal endpoint has several well-populated categories or has a great many categories, in which it becomes a standard continuous variable. When a randomized clinical trial (RCT) is undertaken and deaths can occur, there are disadvantages to excluding the death and analyzing responses only on survivors using death as a competing risk, wh...| Statistical Thinking
Background Consider the problem of comparing two treatments by doing squential analyses by avoiding putting too much faith into a fixed sample size design. As shown here the lowest expected sample size will result from looking at the developing data as often as possible in a Bayesian design. The Bayesian approach computes probabilities about unknowns, e.g., the treatment effect, and one can update the current evidence base as often as desired, knowing that the current information has made pre...| Statistical Thinking