In a discovery that could expand the array of current cancer immunotherapy treatments, scientists at Harvard Medical School have identified a new molecular brake that hinders the ability of T cells to attack tumors.| medicalxpress.com
Cancer of the voice box or larynx is an important public health burden. In 2021, there were an estimated 1.1 million cases of laryngeal cancer worldwide, and approximately 100,000 people died from it. Risk factors include smoking, alcohol abuse, and infection with human papillomavirus. The prognosis for laryngeal cancer ranges from 35% to 78% survival over five years when treated, depending on the tumor's stage and its location within the voice box.| medicalxpress.com
Experts have created a customizable, web-based tool that provides state and local leaders with tailored resources to reduce lung cancer mortality rates and advance treatment. The tool's development and features are described in an article published in Cancer.| medicalxpress.com
Fragmented care—receiving medical treatment at more than one facility—has been associated with both positive and negative outcomes for cancer patients depending on a number of factors such as cancer type and treatment venue.| medicalxpress.com
A team led by the Institute for Bioengineering of Catalonia (IBEC) and the Hospital del Mar Research Institute has developed the MIRO (Micro Immune Response On chip), a device that allows researchers to replicate the characteristics of tumors and their environment using patient cells. It is a tool that can help speed up the development of new cancer therapy treatments as well as select the most suitable ones for each person. The work has been published in the journal Nature Communications.| medicalxpress.com
Women who develop gestational diabetes are not more likely to go on to be diagnosed with breast cancer, according to a study of almost three-quarters of a million mothers to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD; Madrid, 9-13 September).| medicalxpress.com
Rural Americans have higher rates of lung, colorectal and cervical cancers and higher cancer death rates overall compared to their metropolitan counterparts. They also have lower access to cancer screening, treatment and specialty care, are less likely to have access to reliable transportation and health insurance and have higher prevalence of cancer risk factors, like smoking and obesity.| medicalxpress.com
CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the U.S. and a year later in Europe for treating acute lymphoblastic leukemia (ALL). For instance, no effective CAR-T cell therapies for solid tumors exist. Furthermore, CAR-T-induced remissions are not always durable, and the production of CAR-T cells is slow and laborious.| medicalxpress.com
Cong Peng and others at the Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled "NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway," which investigated the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.| medicalxpress.com
Even as they have revolutionized the treatment of certain forms of cancer, CAR T-cell therapies have been shadowed by a significant limitation: Many patients, including those whose cancer goes into full remission, eventually relapse. In a new study, Dana-Farber Cancer Institute researchers report on a technique with the potential to eliminate that problem.| medicalxpress.com
Scientists at St. Jude Children's Research Hospital have created a panel that is able to provide a diagnosis for more than 90% of pediatric cancer patients by sequencing 0.15% of the human genome. The panel is a cost-effective way to test and classify childhood malignancies and to help guide patient treatment.| medicalxpress.com
Mantle cell lymphoma (MCL) is a rare and sometimes ruthless form of non-Hodgkin lymphoma. Even when treatment appears to be successful, the cancer often returns and is difficult to cure.| medicalxpress.com
In a new study, the team led by Étienne Gagnon, Professor in the Department of Microbiology, Infectious Diseases and Immunology at the Université de Montréal and Director of IRIC's Cancer Immunobiology Research Unit, has developed a cell culture protocol that accurately reproduces the characteristic conditions of primary tumors.| medicalxpress.com
A drug that was developed to treat pancreatic cancer has now been shown to increase symptom-free survival in preclinical medulloblastoma models—all without showing signs of toxicity.| medicalxpress.com
If metastases occur in the body, but the original tumor remains undetectable, this is referred to as "cancer of unknown primary" (CUP). But if information on the tissue of origin is missing, neither organ-specific chemotherapy nor targeted drugs are available.| medicalxpress.com
