A 2025 study retrospectively reviewed histopathology slides from 20 trans-identifying females (ages 16–35) who underwent “gender-affirming” gynecologic surgery following 4–63 months of testosterone therapy (mean duration 21.7 ± 17.8 months). Key findings included: A comparison group of 25 benign hysterectomy samples from females of reproductive age showed no transitional or prostatic-type metaplasia, and only 2 cases (8%) […] The post Testosterone induces distinct cellular chan...| Stats for Gender
A 2025 analysis1 of NIH medical records found that 10.3% of males on feminizing hormone therapy developed kidney stones, compared to 4.8% of those not on hormones. The risk was especially elevated for those on both estrogen and antiandrogens, with odds more than 2.5 times higher. The post Males on feminizing hormones face over double the risk of kidney stones. appeared first on Stats for Gender.| Stats for Gender
An application for a judicial review of the Secretary of State’s decision to ban puberty blockers but not cross-sex hormones was heard in the High Court on 21st May. The case was brought by Keira Bell together with two parents. NHS England was an interested party. Although the Court refused permission for a judicial review, […] The post Ban on cross-sex hormones to be considered after court rejects application for JR appeared first on Transgender Trend.| Transgender Trend
A 2025 review summarizes wide-ranging risks tied to estrogen use in trans-identified males: The review emphasizes that many of these risks are under-recognized in clinical practice, raising urgent concerns about safety and informed consent. The post Estrogen use in trans-identified males is associated with a wide range of serious health risks—including blood clots, stroke, cancer, infertility, and cognitive decline. appeared first on Stats for Gender.| Stats for Gender
In a 2025 study in the Journal of Clinical Investigation1, females taking testosterone for gender transition showed biological changes consistent with subclinical kidney stress and tubular injury after three months—including a 134% increase in a urinary marker linked to kidney inflammation (YKL-40) and an 8% rise in an inflammatory blood protein (TNF receptor-1). Although overall […] The post Testosterone use in females triggers biological signs of kidney stress and injury within just thr...| Stats for Gender