This guest blog post is written by Tian Yang, Associate Product Manager at Promega. In the realm of chemical probe development and drug discovery, understanding the interactions between drugs/compounds and their targets is crucial. Two frequently used metrics to characterize these interactions are IC50 and Kd, which guide researchers in evaluating the potential of compounds […] The post Exploring the Relationship Between IC50 and Kd in Pharmacology appeared first on Promega Connections.| Promega Connections
This blog was written by guest author Michael Curtin, Senior Product Manager, Small Molecule Drug Discovery. ATP is the universal energy currency of cells, and thousands of proteins outside the kinase family “spend” it to move cargo, remodel nucleic acids, pump ions, or fold proteins. These ATP-hydrolyzing enzymes—collectively known as ATPases—span functional classes including motor […] The post ATP-Powered Proteins Beyond Kinases – and Why Helicases Are Stealing the Spotlight app...| Promega Connections
This guest blog post is written by Tian Yang, Associate Product Manager at Promega. There are often challenges with translating results from a test tube into a living system, demanding more physiologically relevant assays. In drug discovery, demonstrating a compound’s ability to modulate its target protein in live cells is a critical step in the […]| Promega Connections