The blog discusses the importance of selectivity in drug development and chemical probe use. It highlights advancements in cellular profiling techniques, like chemical proteomics and CETSA-MS, which provide more accurate insights into compound-target interactions. These methods enhance understanding of drug selectivity, enabling identification of novel off-targets and improving therapeutic opportunities. The post Cellular Selectivity Profiling: Unveiling Novel Interactions and More Accurate C...| Promega Connections
This blog was written in collaboration with Tian Yang, Associate Product Manager at Promega. Cancer is often driven not only by genetic mutations, but by changes in how genes are turned on or off—epigenetic alterations. Two key players in this space are bromodomain and extra-terminal (BET) proteins and histone deacetylases (HDACs). BET proteins help activate […]| Promega Connections