Navigating CDH1 and Hereditary Diffuse Gastric Cancer: Evolving Risks, Guidelines, and Counseling Challenges
Hereditary diffuse gastric cancer (HDGC) has long been recognized as one of the most penetrant hereditary cancer syndromes, primarily linked to pathogenic variants in the CDH1 gene. Early reports painted a sobering picture, with lifetime gastric cancer risks estimated at over 80%, often leading to prophylactic total gastrectomy as the “default” recommendation. But in recent years, the story of CDH1 has shifted. New penetrance data, updated guideline recommendations, and a growing understa...| CGA-IGC
