"Forgeries of this calibre make me think anything ever published by Sliwinski, Skorski and their associates is made up. In an ideal world, hundreds of articles by these people showing just tables and graphs should get retracted " - Aneurus Inconstans| For Better Science
The blog discusses the importance of selectivity in drug development and chemical probe use. It highlights advancements in cellular profiling techniques, like chemical proteomics and CETSA-MS, which provide more accurate insights into compound-target interactions. These methods enhance understanding of drug selectivity, enabling identification of novel off-targets and improving therapeutic opportunities. The post Cellular Selectivity Profiling: Unveiling Novel Interactions and More Accurate C...| Promega Connections
Metastasis of melanoma poses significant threats, especially to the brain, with low survival rates once advanced. A new microphysiological system developed by Reed-McBain et al. simulates tumor-stroma interactions in the brain, allowing for detailed metabolic assessments and visualization of nutrient diffusion. This innovative model offers potential improvements in therapeutic screening for melanoma brain metastases. The post Developing an Experimental Model System to Understand the Tumor Mic...| Promega Connections
The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must be faithfully copied. This staggering task happens over and over with extraordinary precision. Decades of research have revealed how dozens of proteins work... The post Licensed to live appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
A critical role for N-cadherin in ovarian follicular development and ovulation is demonstrated with inhibitors or knockout of N-cadherin shown to inhibit ovulation by blocking mechanotransduction of ovulatory genes.| eLife
This blog was written in collaboration with Tian Yang, Associate Product Manager at Promega. Cancer is often driven not only by genetic mutations, but by changes in how genes are turned on or off—epigenetic alterations. Two key players in this space are bromodomain and extra-terminal (BET) proteins and histone deacetylases (HDACs). BET proteins help activate […]| Promega Connections
Nandi N, Tyra LK, Stenesen D, Krämer H. 2017. Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437. eLife 6:e30760. doi: 10.7554/eLife.30760.| eLife
Explore Wnt/β-catenin signaling, its disease relevance, and how live-cell imaging with luminescent assays supports functional studies.| Promega Connections
Chromosomes are glued together during the final stages of cell division by the formation of a liquid-like protein–RNA layer.| EMBL
Learn about our current understanding of malate production, its role in metabolism, and its implications in various disease states.| Promega Connections
