Virginia Tech scientists are probing how mitochondrial stress and calcium overload may cause Alzheimer’s to strike memory circuits first, offering clues to the disease’s earliest breakdown. One of the first parts of the brain affected by Alzheimer’s disease is the entorhinal cortex — a region that plays a big role in memory, spatial navigation, and [...]| SciTechDaily
The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must be faithfully copied. This staggering task happens over and over with extraordinary precision. Decades of research have revealed how dozens of proteins work... The post Licensed to live appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
When the weather’s right, you can find any number of Cold Spring Harbor Laboratory (CSHL) students, faculty, and staff around the gazebo on Bungtown Road. The spot’s popularity is undoubtedly owed to its excellent view of the harbor. But crowning the gazebo is an homage to something arguably just as important to CSHL as its... The post The Adenovirus Gazebo appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
History’s deadliest infectious disease has a new adversary. Although many think of tuberculosis as a disease of the past, it still kills 1.2 million people annually. Last month, scientists at Texas A&M AgriLife Research published a study in Nature, revealing that they had developed a new compound that could be a tuberculosis treatment breakthrough. The… The post Scientists have discovered a potential new treatment for tuberculosis – even drug-resistant strains appeared first on Drug D...| Drug Discovery and Development
A critical role for N-cadherin in ovarian follicular development and ovulation is demonstrated with inhibitors or knockout of N-cadherin shown to inhibit ovulation by blocking mechanotransduction of ovulatory genes.| eLife
This blog was written in collaboration with Tian Yang, Associate Product Manager at Promega. Cancer is often driven not only by genetic mutations, but by changes in how genes are turned on or off—epigenetic alterations. Two key players in this space are bromodomain and extra-terminal (BET) proteins and histone deacetylases (HDACs). BET proteins help activate […]| Promega Connections
Nandi N, Tyra LK, Stenesen D, Krämer H. 2017. Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437. eLife 6:e30760. doi: 10.7554/eLife.30760.| eLife
Explore Wnt/β-catenin signaling, its disease relevance, and how live-cell imaging with luminescent assays supports functional studies.| Promega Connections
Definition An adipocyte cell is a brown, beige, pink, or white fat cell that stores triglyceride droplets, has a secretory function, and/or helps to convert lipids into energy. Fat tissue is primarily composed of adipocytes. An adipocyte can secrete hormones and other effector chemicals that play important roles in metabolism control. Because of its association […] The post Adipocyte appeared first on Biology Dictionary.| Biology Dictionary
Definition The white blood cell or leukocyte is an immune cell that protects the body from endotoxins, invading pollutants, bacteria, and viruses; this broad group of cells also removes dead or damaged cells. White blood cells are split into two main groups – granular and non-granular. Granular white blood cells are basophils, eosinophils, and neutrophils. […] The post White Blood Cell appeared first on Biology Dictionary.| Biology Dictionary
Definition The basal cell is an epithelial stem cell but can also refer to any cell that sits on an epithelial basement membrane. Epithelia are tissues that line the inner and outer surfaces of the body. Basal cells are located in the lower layers of multi-layered epithelium and pockets in single-layered epithelium and divide and […] The post Basal Cell appeared first on Biology Dictionary.| Biology Dictionary
Definition Any blood cell definition involves a variety of cell types, each with specific functions. The primary components of blood are plasma, leukocytes, erythrocytes, and platelets; the latter three are all blood cell examples. Without them, no oxygen transportation through the circulatory system would occur, our blood would not clot, and we would have a […] The post Blood Cell appeared first on Biology Dictionary.| Biology Dictionary
T cell immunity is a key component of the adaptive immune response against pathogens and virus-infected cells. The two main types of effector T cells are helper T cells and cytotoxic T cells. Helper T cells function as immune coordinators and secrete cytokines to activate other immune cells (such as macrophages, B cells, and cytotoxic […] The post T Cell Immunity appeared first on Biology Dictionary.| Biology Dictionary
Satellite cells are multipotent stem cells of the skeletal muscle tissue, and they play a central role in the growth, maintenance, and repair of the muscles. These self-renewing cells are found between the sarcolemma and basement membrane of muscle fibers and are quiescent in most healthy, adult muscle tissue. Satellite cells are activated in response […] The post Satellite Cells appeared first on Biology Dictionary.| Biology Dictionary
Embryonic stem cells are pluripotent cells derived from a 3 – 5 day old human embryo. They have the unique potential to develop into any of the other 200+ human cell types, and can significantly further our understanding of human development and diseases. Embryonic stem cells also have important applications in drug development, and may […] The post Embryonic Stem Cells appeared first on Biology Dictionary.| Biology Dictionary
Definition HeLa cells, named after their original donor Henrietta Lacks, represent the most widely-used human cell line in the field of biological research. The cervical cells of a dying woman were kept alive (without consent) as ‘immortal’ cells in 1951 and fueled research into polio vaccination and isolation of the human immunodeficiency virus. They are […] The post HeLa Cells appeared first on Biology Dictionary.| Biology Dictionary
Definition CAR T-cells (chimeric antigen receptor T-cells) or CAR-Ts are immune cells with engineered receptors that change which antigens these cells respond to. Chimeric antigen receptors are found on the T-cell membrane; chimeric DNA or recombinant DNA refers to a genetically engineered sequence that is manufactured from two different species. These species could be fungal, […] The post CAR T Cells appeared first on Biology Dictionary.| Biology Dictionary
A sperm cell or spermatozoon is a gamete (sex cell) that contains the entire male genome. It has one aim – to fertilize a female egg.| Biology Dictionary
Chromosomes are glued together during the final stages of cell division by the formation of a liquid-like protein–RNA layer.| EMBL
Learn about our current understanding of malate production, its role in metabolism, and its implications in various disease states.| Promega Connections