This post explores the impact of setting particular criteria for “success” in clinical trial designs. A common study design is a “non-inferiority” trial. The goal here is to show that some intervention is not inferior, that is not worse, than some already approved intervention, by some specific definition of not worse. While this may sound straightforward, it can be tricky! Especially because in all clinical trials we are working with a sample of individuals, so there is necessarily u...
