New York City (NYC) experienced a large mpox outbreak in 2022, with 3821 cases. Case counts remained low through most of 2023 at only 184 cases, a mean of 3.5 cases per week. However, incidence increased in 2024, with 191 cases as of 4 May 2024, a mean of 10.6 cases per week. To investigate the evolutionary dynamics underlying this increase in case count, we performed phylogenetic and phylodynamic analysis of the 81 mpox virus (MPXV) genomes sampled in 2023 and 2024 in NYC, sequenced by the N...
