In December 2022, the Democratic Republic of the Congo declared a national outbreak of mpox and an incident management system has been in place since February 2023, based on the increasing number of reported cases. Since September 2023, an outbreak of mpox in South Kivu province has continued to spread within the province and recently to neighbouring North Kivu, driven by sexual contact transmission. A new variant of clade I MPXV has been described in South Kivu. It carries predominantly APOB...