Computational protein design, once considered impossible, has blossomed into a transformative research field with implications for medicine, sustainability, and beyond. In a recent webinar hosted by David Baker, three pioneers in the field—Bill DeGrado, Steve Mayo, and Brian Kuhlman—shared their insights on the origins, evolution, and future of protein design. The post Webinar: Protein Design Then & Now (1988-2024) first appeared on Institute for Protein Design.