What is a BTR file? A file with .btr extension is a database file created by Btrieve transactional database application. Unlike relational database management systems (RBMS), Btrieve is based on Indexed Sequential Access Method (ISAM), which is a way of storing data for fast retrieval. The BTR file stores a collection of records and is used to generate reports as per requirements. BTR files can be opened using Pervasive Btrieve Database Manager, Pervasive PSQL Maintenance Utility, and Legend ...