How Does PCOS Affect Fertility? Before we discuss the best supplement for PCOS fertility, let’s rewind a bit. Polycystic Ovarian Syndrome (PCOS) is an endocrine condition (aka hormonal condition) that affects many women. While this condition can impact women in all stages of life, one of the most common concerns is how it will impact fertility. Insulin resistance and elevated androgens can impact ovulation, causing irregular cycles or anovulation (not ovulating). When it comes to that T...