Scientists at UC Santa Barbara and Northwestern University have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and stacks into strands, or fibrils, of misfolded tau proteins, which then transmit their abnormally folded shape to other normal tau proteins. Misfolded, prion-like proteins drive the progression of tauopathies, a group of neurodegenerative diseases — including Alzheimer’s disease — characterized by the abnormal accumulat...
