Your Guide To Suboxone Fatigue and MAT Treatment Options If you feel tired or sleepy shortly after your suboxone dose, you may be asking: Does suboxone make you tired? For some, the tired feeling comes from the buprenorphine in the medication, one of the active ingredients, which acts quickly after taking suboxone. Suboxone may make […] The post Does Suboxone Make You Tired? appeared first on Purpose Healing Center.