(This post was last updated on: 7/6/2025). Ocean Isle Beach is located in between Holden Beach and Sunset Beach in North Carolina. It is just a bit north of Myrtle Beach, SC. We love taking vacations at Ocean Isle because it is small, quiet and family oriented. We put this travel guide- Ocean Isle, NC Beach Vacation together to show you what an awesome beach it is to visit. Ocean Isle, NC Beach Vacation Travel Guide: We typically book a beach front house through VRBO. This gives us a bit more...