Background Human Immunodeficiency Virus (HIV) pre-exposure prophylaxis (PrEP) prevents HIV transmission but has low uptake among women. Identifying women who could benefit from PrEP remains a challenge. This study developed a women-specific model to predict HIV risk within a year using electronic health record (EHR) data and social determinants of health (SDoH). Methods We conducted a case-control study using EHR and claims data from a centralized patient repository in the Southeastern United...