ticle is to analyze the histopathology of red tattoo reactions for diagnostic purposes and to acquire more insight into pathogenesis. Methods: A retrospective cross-sectional study was conducted by reviewing the histopathology of 74 skin biopsies of patients with allergic red tattoo reactions. Histopathological findings, such as inflammation patterns, inflammatory cells and pigment depth and color, were semi-quantified with an in-house validated scoring system by 2 independent senior investig...