The sixth annual AI4SE & SE4AI Research and Application Workshop will be held on September 17-18, 2025. Organized by SERC and the U.S. Army DEVCOM Armaments Center and hosted by The George Washington University Trustworthy AI Initiative in Washington, DC, this year’s hybrid event will be organized around the theme of “Systems Engineering AI that Works: Assuring Transformative Capabilities and Enabling a Digital Transformation.”