Our research centers on elucidating fundamental principles governing neuronal degeneration and regeneration. Our goal is to learn how to repair and protect neurons after injury and during disease. We employ a variety of models in which to interrogate these processes, including in vitro methods in human neurons and in vivo approaches in the mouse. Recently, we have focused on motor neurons as a tractable neuron type to gain an understanding of their pathophysiology in disease. We are investiga...
