Dear Colleagues, Viruses invites the submission of original research and review articles to this Special Issue, covering challenges in HIV diversity. The articles can cover any level of diversity, from intrapatient immune evasion and development of drug resistance, to global challenges for vaccine design. Reports of research on HIV recombination at all levels, from intrapatient to inter-subtype, are encouraged. Although HIV-1 M-group viruses comprise the majority of global AIDS cases, submiss...