Keywords: Monkeypox virus, Mpox, Outbreak, Human-to-Human, Genomic, APOBEC3, Kinshasa, DRC. The ongoing mpox outbreaks in the Democratic Republic of Congo (DRC) has raised significant public health concerns, particularly due to the emergence of the newly identified viral subclade Ib. Recently, we reported human-to-human transmission through sexual contact involving this subclade (1). This transmission route may be an important factor contributing to the virus’s spread from its initial hotsp...