Background In this study, we investigated the association between COVID-19 vaccination status and all-cause mortality (ACM) rate in the population of the Czech Republic between January 2020 and December 2022. Methods In this retrospective study based on official population-wide individual (record-level) data, we analyzed monthly ACM rates stratified by COVID-19 vaccination status, sex, and age. The ACM was compared to expected mortality based on pre-COVID data. The recipients of the Janssen v...