Children with Cushing’s disease whose pituitary tumors carry USP8 gene mutations tend to have larger, more invasive tumors and face a higher risk of persistent or recurrent disease after surgery, a study reports. While inherited mutations do not cause most pediatric cases, non-inherited mutations appear to influence tumor size and treatment outcomes, particularly in USP8. […] The post USP8 mutations tied to worse outcomes in Cushing’s children appeared first on Cushing's Disease News.
