Retinoids, Antibiotics, and Benzoyl Peroxide Top the List The Essential Info The 5 most frequently prescribed acne medications are: *Isotretinoin comes with severe and potentially lifelong side effects, and is only approved for use in people with severe and scarring acne that does not respond to other treatments. However, because of its effectiveness, doctors sometimes … The post Which Prescriptions Do Doctors Prescribe Most Often for Acne? appeared first on Acne.org.