Introduction: Receiving touch is of critical importance for human well-being. A number of studies have shown that touch promotes mental and physical health. However, effect sizes differ considerably across studies and potential moderators of touch interventions remain unknown to this day. Methods We conducted a preregistered (CRD42022304281) systematic review and a large-scale multivariate multilevel meta-analysis encompassing 137 studies in healthy participants and patients (166 cohorts, 961...