Orthobiologics is the science of harnessing and concentrating substances (substrates) that occur naturally in the body. It is theorized that in higher concentrations, biologics may help to enhance (or) improve the healing process. Orthobiologics and bone substitutes represent groundbreaking advancements in regenerative medicine. By Asim Raja, DPM, FACFAS The post No-Nonsense Recap: Orthobiologics and Bone Substitutes: A Primer first appeared on Lower Extremity Review Magazine.