Introduction: Non-functioning adrenal incidentaloma (NFAI) is a frequently diagnosed since the increased use of radiological examinations. The recent studies have shown that NFAI might have negative cardiometabolic effects and increased cardiovascular risk. The aim of this case control study was to determine the relationship between NFAI, CRP-hs, uric acid and cardiovascular risk (CVR) based on GLOBORISK algorithm of Tunisia.