1. Insanity (noun): Severe mental illness. 2. Insanity (noun): Extreme irrationality or foolishness. 3. Insanity (noun): A disrupted state of mind affecting perception or behavior. "Insanity" Definition: What Does "Insanity" Mean? “Insanity” describes a severe mental illness that impairs perception of reality. Courts use it to define a defense where mental disorder removes legal responsibility. […] The post Insanity: Definition, Meaning, and Examples appeared first on US Dictionary.