How many cities are there in South Carolina? There are a total of 376 towns and cities in the state of South Carolina. Top 10 biggest cities by population are Columbia, Charleston, North Charleston, Mount Pleasant, Rock Hill, Greenville, Summerville, Sumter, Hilton Head Island, and Florence while top ten largest cities by land area are Columbia, Charleston, North Charleston, Bluffton, Hardeeville, Mount Pleasant, Ridgeland, Hilton Head Island, Goose Creek, and Rock Hill.
