A 2025 analysis1 of NIH medical records found that 10.3% of males on feminizing hormone therapy developed kidney stones, compared to 4.8% of those not on hormones. The risk was especially elevated for those on both estrogen and antiandrogens, with odds more than 2.5 times higher. The post Males on feminizing hormones face over double the risk of kidney stones. appeared first on Stats for Gender.| Stats for Gender
A 2025 Swiss follow‑up study1 (mean 27.5 years post‑surgery) found prolapse rates highest among those with peritoneal vaginoplasty (83%), followed by penile‑inversion techniques (17%) and intestinal vaginoplasty (14%). Surgical repairs often reduced symptoms but highlight long‑term complications rarely discussed before transition.| Stats for Gender
In a large sample of Finnish adolescents (N = 130,372), Heino et al. (2021) found that trans identities were more strongly associated with perpetrating bullying than being bullied. Youth identifying as non-binary reported the highest rates of both bullying others and being bullied. Experiences of bullying and bullying others according to gender identity,% (n). Regression […] The post Trans identities are more strongly associated with perpetration of bullying than subjection to bullying. app...| Stats for Gender
A 2025 systematic review and meta-analysis of 29 studies (28 included in meta-analysis) involving 2,674 individuals found that “gender-affirming” hormone therapy led to statistically significant body mass index (BMI) increases. The mean age across studies ranged from 16 to 56 years, and no prior puberty suppression was reported before the initiation of GAHT. The researchers […]| Stats for Gender
An analysis of the 2005−2015 Swedish Total Population and Prescribed Drug Registers examined 2,679 adults diagnosed with gender incongruence. Compared to the general population, these individuals were 3.95 times more likely to receive antidepressant prescriptions and 3.43 times more likely to receive anxiolytic (anti-anxiety) prescriptions. The study also found they were six times more likely […] The post One study found adults diagnosed with gender incongruence were nearly four times mor...| Stats for Gender
A 2021 study in the Journal of Sexual Medicine1 found that trans-identified adolescents in the US military healthcare system were prescribed psychotropic medications (such as antidepressants, sleep aids, antipsychotics, and mood stabilizers) at more than double the rate of their siblings (IRR = 2.57), with prescriptions increasing after “gender-affirming pharmaceutical initiation” (IRR = 1.67). The study compared mental health diagnoses, […] The post Trans-identified adolescen...| Stats for Gender
More than a third of UK residents in a 2023 survey1 by Murray Blackburn Mackenzie—a Scottish independent policy analysis collective—did not know that “transgender women” are natal males. The findings show significant misunderstanding of the term and emphasize the need for clearer language in policy and media communication. The post More than a third of UK residents in a survey did not know that “transgender women” are male. appeared first on Stats for Gender.| Stats for Gender
Based on a 2019 review, genital surgery as part of medical transition is generally less common than chest surgery, with reported rates of 25–50% for transmen (natal females) and 5–10% for transwomen (natal males). These estimates come from a range of surveys and clinical reports.| Stats for Gender
A 2025 U.S. national database study1 examined over 107,000 adults diagnosed with gender dysphoria to compare those who did and did not undergo “gender-affirming” surgery. Using matched cohorts controlling for age, race, and ethnicity, the study found significantly higher risks of depression, anxiety, suicidal ideation, and substance use disorders within two years after surgery. For […] The post “Gender-affirming” surgery is associated with increased risk of depression, anxiety, suic...| Stats for Gender
Performance data from Little Athletics Australia reveals that boys outperform girls in every track and field event from under-9 to under-15 age groups, even prior to puberty. This challenges the common claim that pre-pubertal boys or those on puberty blockers have no competitive edge over girls. The male performance advantage appears early in childhood and […] The post Boys show a clear athletic advantage over girls even before puberty. appeared first on Stats for Gender.| Stats for Gender
A 2025 case series1 from Helsinki University Hospital reviewed nine adults who sought medical detransition after previously receiving “gender-affirming” treatments. Seven were natal females and all expressed “major regret”; both natal males expressed “minor regret.” The average time from diagnosis to regret was 7 years. Patients had used hormones for an average of 7 years […] The post A Finnish study found detransitioners commonly had psychiatric comorbidities and childhood trau...| Stats for Gender
A 2025 review summarizes wide-ranging risks tied to estrogen use in trans-identified males: The review emphasizes that many of these risks are under-recognized in clinical practice, raising urgent concerns about safety and informed consent. The post Estrogen use in trans-identified males is associated with a wide range of serious health risks—including blood clots, stroke, cancer, infertility, and cognitive decline. appeared first on Stats for Gender.| Stats for Gender
In a 2022 study1 published in the Journal of Sexual Medicine, researchers analyzed 70.3 million electronic health records from 46 healthcare organizations to examine mental health outcomes in men using testosterone therapy. The study compared 263,579 men who used testosterone to over 17.8 million men who did not. Results showed testosterone use was independently associated […] The post Testosterone therapy is associated with nearly doubled depression risk and 52% higher suicide attempt rate...| Stats for Gender
In a 2025 study in the Journal of Clinical Investigation1, females taking testosterone for gender transition showed biological changes consistent with subclinical kidney stress and tubular injury after three months—including a 134% increase in a urinary marker linked to kidney inflammation (YKL-40) and an 8% rise in an inflammatory blood protein (TNF receptor-1). Although overall […] The post Testosterone use in females triggers biological signs of kidney stress and injury within just thr...| Stats for Gender
A study by Abern et al. surveyed 996 trans-identified adults and found that 50% of females reported experiencing sexual assault, compared to 37% of males. The post Trans-identified females report higher rates of sexual assault than their male counterparts. appeared first on Stats for Gender.| Stats for Gender
A 2025 systematic review and meta-analysis examined 25 studies on pelvic floor outcomes after genital “gender-affirming” surgery. The findings show a high prevalence of complications among both male and female patients: Type of Dysfunction Males (vaginoplasty) Females (hysterectomy & phalloplasty) Pelvic organ prolapse 1–7.5% 3.8% Urinary incontinence up to 15% up to 50% Urinary irritative […] The post Genital surgery is associated with high rates of pelvic floor and sexual dysfunctio...| Stats for Gender
A 2025 study from Argentina found that 26.6% of female adults presenting for “gender-affirming hormone therapy” had polycystic ovary syndrome (PCOS) prior to starting any hormonal treatment. PCOS is a hormonal disorder characterized by irregular periods, excess male hormone levels, and cysts on the ovaries. This rate is 2-3 times higher than the 8-13% prevalence […] The post Polycystic ovary syndrome (PCOS) is more prevalent in females seeking medical transition. appeared first on Stats...| Stats for Gender
A 2024 review by Sallie Baxendale1 extensively examined the neuropsychological impacts of puberty blockers. The review indicated that animal studies showed a non-reversible negative impact on cognitive and behavioral functions. In human studies, the evidence suggested detrimental effects on IQ among those treated with puberty blockers for precocious puberty. Specifically, one study documented an average […] The post Puberty blockers potentially have a negative impact on neuropsychological f...| Stats for Gender
Dhejne et al. (2011)1 conducted the longest follow-up study to date on the outcomes of “sex reassignment surgery”, covering a period of 30 years (1973-2003) and involving 324 individuals in Sweden. The study compared these individuals to matched controls based on birth year and sex, revealing that those who had undergone surgery exhibited a significantly […] The post People who have undergone cross-sex surgery are over 19 times more likely to die by suicide than the general population a...| Stats for Gender
A 2024 study by da Silva et al1. found that 94.1% of 68 trans-identified females using testosterone experienced pelvic dysfunctions typically seen in postmenopausal women, including urinary (86.7%), sexual (52.9%), and bowel (45.6%) problems. These symptoms appeared as early as age 18, with an average onset age of 28. This early onset of menopausal-like symptoms […] The post Long-term testosterone use in females may induce early menopause, leading to pelvic dysfunction, increased mortality ...| Stats for Gender
