Engineering Physiology The primary focus of Feng Zhang’s work is to improve human health by discovering ways to modify cellular function and activity – including the restoration of diseased, stressed, or aged cells to a more healthful state. His team is developing new molecular technologies to modify the cell’s genetic information, vehicles to deliver these […]| MIT McGovern Institute
Scientists at the McGovern Institute and the Broad Institute of MIT and Harvard have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. The protein they created, called NovaIscB, can be adapted to make precise changes to the genetic code, modulate the activity of specific genes, or carry out other editing tasks. Because its small size simplifies delivery to cells, NovaIscB’s developers say it is a promising candidate for deve...| MIT McGovern Institute
One in every eight people—970 million globally—live with mental illness, according to the World Health Organization, with depression and anxiety being the most common mental health conditions worldwide. Existing therapies for complex psychiatric disorders like depression, anxiety, and schizophrenia have limitations, and federal funding to address these shortcomings is growing increasingly uncertain.| MIT McGovern Institute
One in every eight people—970 million globally—live with mental illness, according to the World Health Organization, with depression and anxiety being the most common mental health conditions worldwide. Existing therapies for complex psychiatric disorders like depression, anxiety, and schizophrenia have limitations, and federal funding to address these shortcomings is growing increasingly uncertain. Patricia and James […]| MIT McGovern Institute
Images of Mind John Gabrieli’s goal is to understand the organization of memory, thought, and emotion in the human brain. In collaboration with clinical colleagues, Gabrieli uses brain imaging to better understand, diagnose, and select treatments for neurological and psychiatric diseases. A major focus of the Gabrieli lab is the neural basis of learning in […]| MIT McGovern Institute
Press Mentions| MIT McGovern Institute
From toddlers’ timeouts to criminals’ prison sentences, punishment reinforces social norms, making it known that an offender has done something unacceptable. At least, that is usually the intent—but the strategy can backfire. When a punishment is perceived as too harsh, observers can be left with the impression that an authority figure is motivated by something […] The post Learning from punishment appeared first on MIT McGovern Institute.| MIT McGovern Institute
Imagine a ball bouncing down a flight of stairs. Now think about a cascade of water flowing down those same stairs. The ball and the water behave very differently, and it turns out that your brain has different regions for processing visual information about each type of physical matter. In a new study, MIT neuroscientists […] The post How the brain distinguishes oozing fluids from solid objects appeared first on MIT McGovern Institute.| MIT McGovern Institute
Exploration is essential to learning—and a new study from scientists at MIT’s McGovern Institute suggests that students may be less willing to explore if they come from a low socioeconomic environment. The study, which focused on adolescents and was published July 9, 2025, in the journal Nature Communications, shows how differences in learning strategies might […]| MIT McGovern Institute
MIT researchers have developed a new bionic knee that can help people with above-the-knee amputations walk faster, climb stairs, and avoid obstacles more easily than they could with a traditional prosthesis.| MIT McGovern Institute
The McGovern Institute and the Department of Brain and Cognitive Sciences are pleased to announce the appointment of Sven Dorkenwald as an assistant professor starting in January 2026. A trailblazer in the field of computational neuroscience, Dorkenwald is recognized for his leadership in connectomics—an emerging discipline focused on reconstructing and analyzing neural circuitry at unprecedented […] The post MIT’s McGovern Institute and Department of Brain and Cognitive Sciences welcom...| MIT McGovern Institute
The European Molecular Biology Organization (EMBO), a professional non-profit organization dedicated to promoting international research in life sciences, announced its new members today. Among the 69 new members recognized for their outstanding achievements is Feng Zhang, the James and Patricia Poitras Professor of Neuroscience at MIT and an investigator at the McGovern Institute. Zhang, who […]| MIT McGovern Institute
Launched in February of this year, the MIT Generative AI Impact Consortium (MGAIC), a presidential initiative led by MIT’s Office of Innovation and Strategy and administered by the MIT Stephen A. Schwarzman College of Computing, issued a call for proposals, inviting researchers from across MIT to submit ideas for innovative projects studying high-impact uses of generative AI models.| MIT McGovern Institute
Neurobiology of Mental Computations How does the brain give rise to the mind? How do neurons, circuits, and synapses in the brain encode knowledge about objects, events, and other structural and causal relationships in the environment? Research in Mehrdad Jazayeri’s lab brings together ideas from cognitive science, neuroscience, and machine learning with experimental data in […]| MIT McGovern Institute
The human brain is very good at solving complicated problems. One reason for that is that humans can break problems apart into manageable subtasks that are easy to solve one at a time.| MIT McGovern Institute
When navigating a place that we’re only somewhat familiar with, we often rely on unique landmarks to help make our way. However, if we’re looking for an office in a brick building, and there are many brick buildings along our route, we might use a rule like looking for the second building on a street, […] The post How the brain distinguishes between ambiguous hypotheses appeared first on MIT McGovern Institute.| MIT McGovern Institute
Scientists at the McGovern Institute and the Broad Institute of MIT and Harvard have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. The protein they created, called NovaIscB, can be adapted to make precise changes to the genetic code, modulate the activity of specific genes, or […]| MIT McGovern Institute
Engineering the Brain Ed Boyden develops advanced technologies for analyzing, engineering, and simulating brain circuits to reveal and repair the fundamental mechanisms behind complex brain processes. Boyden may be best known for pioneering optogenetics, a powerful method that enables scientists to control neurons using light. He also led the team that created expansion microscopy, which expands nanoscale […]| MIT McGovern Institute
Nearly 50 years ago, neuroscientists discovered cells within the brain’s hippocampus that store memories of specific locations. These cells also play an important role in storing memories of events, known as episodic memories. While the mechanism of how place cells encode spatial memory has been well-characterized, it has remained a puzzle how they encode episodic […]| MIT McGovern Institute
Placebos are inert treatments, generally not expected to impact biological pathways or improve a person’s physical health. But time and again, some patients report that they feel better after taking a placebo. Increasingly, doctors and scientists are recognizing that rather than dismissing placebos as mere trickery, they may be able to help patients by harnessing […]| MIT McGovern Institute
Using functional magnetic resonance imaging (fMRI), neuroscientists have identified several regions of the brain that are responsible for processing language. However, discovering the specific functions of neurons in those regions has proven difficult because fMRI, which measures changes in blood flow, doesn’t have high enough resolution to reveal what small populations of neurons are doing. […]| MIT McGovern Institute
Language is a defining feature of humanity, and for centuries, philosophers and scientists have contemplated its true purpose. We use language to share information and exchange ideas—but is it more than that? Do we use language not just to communicate, but to think? In the June 19, 2024, issue of the journal Nature, McGovern Institute […]| MIT McGovern Institute
