Lysosomal changes promote longevity by modifying histones and transmitting these alterations into the germline, enabling C. elegans offspring to inherit lifespan benefits from their parents. The post Epigenetic Mechanisms Explain Inheritance of Longevity Markers in <i>C. Elegans</i> appeared first on GEN - Genetic Engineering and Biotechnology News.| GEN – Genetic Engineering and Biotechnology News
Bridge recombinase technology developed for use in human cells allows scientists to manipulate large genomic regions by inserting new genes, deleting entire gene clusters, or inverting regulatory sequences. The post Bridge Recombinase Platform Enables Megabase-Scale Human Genome Rearrangements appeared first on GEN - Genetic Engineering and Biotechnology News.| GEN – Genetic Engineering and Biotechnology News
To quantify the impacts on biomedical research and innovation that NIH funding cuts might have, researchers analyzed small-molecule drug patents to determine how many NIH funded projects were involved in the discovery and development of those drugs. The post NIH Funding Cuts’ Impact on Drug Discovery and Development appeared first on GEN - Genetic Engineering and Biotechnology News.| GEN – Genetic Engineering and Biotechnology News
Whether you’re just starting your intensification journey or looking to scale it to the next level, this eBook offers the strategic foundation and operational perspective to help you move forward. The post Complexity: Simplified. The Process Intensification Playbook appeared first on GEN - Genetic Engineering and Biotechnology News.| GEN – Genetic Engineering and Biotechnology News
In this GEN webinar, our expert speaker(s) will share real-world experiences and strategies for improving product recovery and consistency during downstream processing. The post Why Cell Quality Erodes During Downstream Processing and How to Prevent It appeared first on GEN - Genetic Engineering and Biotechnology News.| GEN – Genetic Engineering and Biotechnology News
In this GEN webinar, our expert speakers, Karessa White, PhD, and Bud Halim, PhD, will present a systematic approach for identifying oligomers, HMWs, and aggregates in biotherapeutics manufacturing. The post Hidden Threats: High-Throughput Strategies to Detect Aggregates in Biotherapeutics appeared first on GEN - Genetic Engineering and Biotechnology News.| GEN – Genetic Engineering and Biotechnology News
Using CRISPR screens, scientists have found ways to modify genes to boost the persistence and function of immunotherapies in multiple myeloma cases. The post CRISPR Screens Pinpoint Genetic Tweaks That Improve CAR T Therapies for Multiple Myeloma appeared first on GEN - Genetic Engineering and Biotechnology News.| GEN – Genetic Engineering and Biotechnology News
Scientists used sequencing technology to identify exactly where human chromosomes break and recombine to form Robertsonian chromosomes. The results may indicate how repetitive DNA, once considered “junk,” may play a central role in genome organization and evolution. The post Genome Evolution Revealed by Robertsonian Chromosome Rearrangements appeared first on GEN - Genetic Engineering and Biotechnology News.| GEN – Genetic Engineering and Biotechnology News
The study met its prespecified primary endpoint of demonstrating a statistically significant slowing of disease progression as measured by the composite Unified Huntington’s Disease Rating Scale (cUHDRS) at 36 months. The post Gene Therapy Significantly Slows Huntington Disease Progression appeared first on GEN - Genetic Engineering and Biotechnology News.| GEN – Genetic Engineering and Biotechnology News
Connecting clinical centers to industrial-grade autologous therapy manufacturing enhances therapeutics and processing efficiency.| GEN - Genetic Engineering and Biotechnology News
Results reported in a preprint connect localized signals in the brain to aging-related changes in immune cells in mouse models.| GEN - Genetic Engineering and Biotechnology News
Two papers reveal insights into how decision-making unfolds across the entire brain in mice at single-cell resolution.| GEN - Genetic Engineering and Biotechnology News
Antibodies from a person who had previously been infected with mpox provides full protection from severe illness and death in mice.| GEN - Genetic Engineering and Biotechnology News
The invention of CRISPR and DNA sequencing has provided the necessary tools for rapidly engineering CHO cells along with a parts list.| GEN - Genetic Engineering and Biotechnology News
The movement of epithelial cells during wound healing is mediated by the endoplasmic reticulum, which senses the curvature of wound gaps.| GEN - Genetic Engineering and Biotechnology News
Researchers suggest targeting inflammation may offer a promising therapeutic strategy at the intersection of cancer and cardiovascular disease.| GEN - Genetic Engineering and Biotechnology News
VantAI's AI platform will accelerate programmable protein interaction therapies across Halda's cancer and immunology indications.| GEN - Genetic Engineering and Biotechnology News
Researchers demonstrate that an engineered antibody improves a class of drugs that has struggled to make good on its early promise.| GEN - Genetic Engineering and Biotechnology News
Landmark single-cell dataset of one billion cells will be used to train new AI models to advance understanding of cellular behavior and gene function.| GEN - Genetic Engineering and Biotechnology News
Trained on data covering 1.5 billion years of evolution, CZI’s new generative AI model probes cellular biology across species for therapeutic applications.| GEN - Genetic Engineering and Biotechnology News
Copyright © 2025 Sage Publications or its affiliates, licensors, or contributors. All rights reserved, including those for text and data mining and training of large language models, artificial intelligence technologies, or similar technologies.| GEN - Genetic Engineering and Biotechnology News
GREmLN leverages a graph-based architecture to represent gene-gene interactions to predict cell behavior for therapeutic applications.| GEN - Genetic Engineering and Biotechnology News
Agilis Biotherapeutics has been awarded a Cooperative Research and Development Agreement by National Center for Accelerating Translational Sciences (NCATS) to facilitate development of the company’s gene-therapy candidate for aromatic L-amino acid decarboxylase (AADC) deficiency.| Powell Gene Therapy Center » College of Medicine » University of ...
Eight babies, born following Mitochondrial Donation treatment to reduce transmission of mitochondrial DNA disease, show no signs of illness.| GEN - Genetic Engineering and Biotechnology News