Rise Therapeutics plans to launch a Phase 1 clinical trial testing R-2487, its experimental oral therapy for autoimmune diseases, in people with Sjögren’s disease. R-2487, which leverages bacterial proteins to suppress the abnormal immune responses in autoimmune diseases like Sjögren’s, “is disease-modifying, focusing on long-term immune correction rather than short-term symptom relief,” Christian Furlan Freguia, […] The post Rise’s R-2487 moves toward clinical testing as Sjögr...| Sjogren's Disease News – The Web's Daily Resource for Sjogren's Disease News
Primary Sjögren’s disease-associated interstitial lung disease tends to lead to worse outcomes in men, a study shows.| Sjogren's Disease News
Immune B-cells that contain the receptor protein CD226 may play a role in the development and clinical manifestations of primary Sjögren’s disease, making CD226 a possible target for future treatments, a study reports. Data indicated that people with Sjögren’s had proportionally more CD226-positive B-cells in their bloodstream than their healthy counterparts. The prevalence of these […] The post B-cells containing CD226 may be Sjögren’s biomarker, therapy target appeared first on S...| Sjogren's Disease News – The Web's Daily Resource for Sjogren's Disease News
A traditional Chinese medicine formulation called Qihuang Jianpi ZiShen Granule (QJZG) may help to alleviate Sjögren’s disease by reducing inflammatory molecules and associated tissue damage, according to computer simulations and tests in a cell model of the disease. “This study provides evidence supporting the use of Chinese medicine in treating [Sjögren’s disease],” researchers wrote. “However, […] The post Traditional Chinese medicine QJZG may help ease Sjögren’s disease a...| Sjogren's Disease News – The Web's Daily Resource for Sjogren's Disease News
The new name, Sjögren’s disease, is meant to better reflect the condition's nature and to provide clarity in clinical and research settings.| Sjogren's Disease News
Telitacicept safely and effectively eased disease activity in adults with primary Sjögren’s disease, according to data from a now-complete Phase 3 clinical trial conducted in China. Because the trial met its primary goal, developer Remegen plans to ask China’s regulator, the Center for Drug Evaluation of the National Medical Products Administration, to approve the drug, according […] The post Telitacicept shows promise for primary Sjögren’s in Phase 3 trial appeared first on Sjogre...| Sjogren's Disease News – The Web's Daily Resource for Sjogren's Disease News
Novartis' therapy candidate ianalumab safely and effectively eased disease activity for adults with active Sjögren's in two clinical trials.| Sjogren's Disease News
Levels of the receptor protein Mer tyrosine kinase (MerTK) in small salivary glands may be a useful marker for tracking disease activity and estimating tissue damage in Sjögren’s disease, a study reports. Researchers found that elevated MerTK, which plays a role in immune inflammation, was significantly associated with more disease activity and tissue damage. They […] The post MerTK protein in salivary glands could help track Sjögren’s activity appeared first on Sjogren's Disease News.| Sjogren's Disease News – The Web's Daily Resource for Sjogren's Disease News
Prompt treatment for Sjögren’s was found to improve recovery, and reduce the risk of recurrence, in patients who develop ischemic stroke.| Sjogren's Disease News
Those with lung fibrosis showed distinct CT scans, had a shorter disease duration than those with interstitial lung disease without fibrosis.| Sjogren's Disease News
The Sjögren’s Foundation is asking people to make a pledge to take action for World Sjögren’s Day on July 23 to help support the foundation’s research and education programs. Longtime Sjögren’s Foundation supporter Debby Vivari will donate $2 for the first 5,000 pledges and anyone can make a pledge to honor themselves, others with Sjögren’s, […] The post Sjögren’s Foundation encourages ‘action’ on World Sjögren’s Day appeared first on Sjogren's Disease News.| Sjogren's Disease News – The Web's Daily Resource for Sjogren's Disease News
Anti-SSB antibodies may predict decreased lung function in primary Sjögren’s patients with interstitial lung disease, a study found.| Sjogren's Disease News
Sjögren’s disease is a chronic autoimmune disorder affecting the entire body but best characterized by dry eyes and a dry mouth.| Sjogren's Syndrome News
Ines Martins is the managing science editor for Sjogren's Syndrome News with a PhD in biomedical sciences. She assigns, edits, and fact-checks articles on Sjogren's syndrome.| Sjogren's Syndrome News
Patricia Inacio is a science writer for Sjogren's Syndrome News with a PhD in cell biology. She covers the latest news and information on a variety of Sjogren's syndrome topics.| Sjogren's Syndrome News
The dysfunction of regulatory T-cells, or Tregs, drives the development of Sjögren's disease, according to a new mouse study.| Sjogren's Syndrome News
Andrea Lobo is a science writer for Sjogren's Syndrome News with a PhD in cell biology/neurosciences. She covers the latest news and information on a variety of Sjogren's topics.| Sjogren's Syndrome News
Ultrasound evaluation of the salivary glands may be useful and effective for diagnosing Sjögren’s syndrome, a new study reports.| Sjogren's Syndrome News
Researchers identified clinical factors that may help to distinguish the different causes of joint pain in Sjögren’s syndrome.| Sjogren's Syndrome News
Rituximab safely and effectively treated sudden interstitial lung disease in a man with undiagnosed primary Sjögren’s syndrome.| Sjogren's Syndrome News
The activity of "clock genes" that regulate the body’s internal clock, or circadian rhythm, is impaired in Sjögren’s, a mouse model shows.| Sjogren's Syndrome News
Blood levels of anti-AQP5 antibodies may be used as a biomarker to diagnose primary Sjögren’s disease, according to a new study from China.| Sjogren's Syndrome News
Age, disease duration, and blood levels of inflammatory markers can distinguish Sjögren’s syndrome patients with interstitial lung disease.| Sjogren's Syndrome News
In a study, low TTR blood levels correlated with higher markers of inflammation, low BMI, and higher primary Sjögren's disease activity.| Sjogren's Syndrome News
Sjögren's syndrome is a rare autoimmune disorder that leads to dry eyes and mouth. The exact cause of the syndrome remains unknown.| Sjogren's Syndrome News
Primary Sjögren’s syndrome patients who haven't received treatment for it show gut microbiota disturbances like those seen with SLE.| Sjogren's Syndrome News
Sjögren's syndrome is linked to a significantly increased risk of miscarriage and other adverse pregnancy problems, a meta-analysis finds.| Sjogren's Syndrome News
Lindsey Shapiro is a science writer for Sjogren's Syndrome News with a PhD in neuroscience. She covers the latest news and information on a variety of Sjogren's syndrome topics.| Sjogren's Syndrome News
Marta Figueiredo is a science writer for Sjogren's Syndrome News with a PhD in biomedical sciences. She covers the latest news and information on a variety of Sjogren's syndrome topics.| Sjogren's Syndrome News
Sjögren’s syndrome is typically diagnosed through a series of tests and questions related to a patient's medical history.| Sjogren's Syndrome News
Marisa Wexler is a senior science writer for Sjogren's Syndrome News with an MS in cellular and molecular pathology. She covers the latest news and information on a variety of Sjogren's syndrome topics.| Sjogren's Syndrome News
The proteins CTSS and GSTO1 were able to accurately distinguish people with Sjögren's syndrome from people without the condition.| Sjogren's Syndrome News
Sjögren's syndrome's most common symptoms are dry eyes and a dry mouth. Others can include joint pain, skin rashes, dry skin, vaginal dryness, and fatigue.| Sjogren's Syndrome News
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Margarida Maia is a science writer for Sjogren's Syndrome News with a PhD in biomedical sciences. She covers the latest news and information on a variety of Sjogren's syndrome topics.| Sjogren's Syndrome News
Sharing personal stories, educating, and raising funds for research and advocacy, World Sjögren’s Day is observed annually July 23.| Sjogren's Syndrome News
A photo-detection method can measure lactoferrin in dry eye disease patients' tears, making it a possible biomarker of disease severity.| Sjogren's Syndrome News
The annual Sjogren's Awareness Month event in April is designed to showcase the disorder and the needs of the Sjögren’s community.| Sjogren's Syndrome News
Primary Sjögren’s patients with extra-glandular symptoms have higher CXCL9 levels than those whose disease affects the saliva and tear glands.| Sjogren's Syndrome News
In adults with Sjögren’s syndrome with missing teeth, implant-supported overdentures may help with chewing, helping to boost quality of life.| Sjogren's Syndrome News
Autologous serum and platelet-rich eye drops work equally well to relieve eye dryness in Sjögren’s, but the latter take less time to prepare.| Sjogren's Syndrome News