The Academic Access Program gives Val Watts advanced tools to accelerate his adenylyl cyclase research with limited grant funds.| Promega Connections
Brady Musson, Director of Global Logistics, addresses how Promega is navigating ongoing challenges in the logistics industry.| Promega Connections
New lyophilization equipment at Promega Madison will ensure supply continuity and open new product formulation opportunities.| Promega Connections
The DCi transplant lab was the first to buy a Maxwell instrument in 2005. Today, Maxwell still supports their organ transplant testing.| Promega Connections
MacKenzie Gartner, Lead Technologist at DCi, operates a Maxwell® instrument. | Promega Connections
Why it matters: As human populations expand and environments shift, the human–animal interface grows—and with it, the risk of pathogens jumping species. Key finding: In an urban shelter cohort, Onchocerca lupi was detected in ~2% of dogs using a sensitive qPCR assay (1.9%), slightly higher than conventional PCR (1.6%). Takeaway: Monitoring shelter populations can surface low visibility threats and inform veterinary and public health response. The post What Shelter Dogs Can Tell Us About E...| Promega Connections
Targeted protein degradation (TPD) is an emerging drug discovery strategy that offers an entirely different approach to tackle disease-relevant proteins, including classic “undruggable” targets. Instead of inhibiting protein function, small molecules like PROTACs and molecular glues co-opt the cell’s own ubiquitin-proteasome system to eliminate specific proteins altogether. But as this targeted approach gains traction, it also […] The post A New View of Protein Degradation with HiBiT...| Promega Connections
This blog discusses NEAT1 supports granulosa cell survival and estrogen production through the miR-204-5p/ESR1 pathway.| Promega Connections
Polyserine targeting helps prevent tau aggregation, offering a new approach to treat neurodegeneration.| Promega Connections
Thoughts, tech tips and news about science| Promega Connections
As biologics grow more complex, so do the tools required to understand, validate, and ensure their quality. From monoclonal antibody cocktails to antibody-drug conjugates (ADCs) and cell therapies, developers are navigating new frontiers in potency, purity, and functional characterization. Promega’s R&D scientists have been actively contributing to this evolving dialogue through respected industry platforms like […] The post At the Forefront of Biologics Characterization: Insights from ...| Promega Connections
The blog discusses the importance of selectivity in drug development and chemical probe use. It highlights advancements in cellular profiling techniques, like chemical proteomics and CETSA-MS, which provide more accurate insights into compound-target interactions. These methods enhance understanding of drug selectivity, enabling identification of novel off-targets and improving therapeutic opportunities. The post Cellular Selectivity Profiling: Unveiling Novel Interactions and More Accurate C...| Promega Connections
This blog was contributed by guest Avi Aggarwal, 2025 summer intern at Promega. If you’ve ever scratched your head over inconsistent experimental results, especially ones that seem to fluctuate for no obvious reason—you’re not alone. Sometimes the problem isn’t your pipetting, your reagents, or even your protocol. It might be the room itself. Changes in […] The post Is Your Lab Environment Messing with Your Results? How to Spot the Signs Early appeared first on Promega Connections.| Promega Connections
Metastasis of melanoma poses significant threats, especially to the brain, with low survival rates once advanced. A new microphysiological system developed by Reed-McBain et al. simulates tumor-stroma interactions in the brain, allowing for detailed metabolic assessments and visualization of nutrient diffusion. This innovative model offers potential improvements in therapeutic screening for melanoma brain metastases. The post Developing an Experimental Model System to Understand the Tumor Mic...| Promega Connections
Incorporating live-cell kinetic analysis helps answer questions about how fast, how thoroughly and how sustainably a degrader works| Promega Connections
The blog highlights the contributions of the Minderoo OceanOmics Centre to marine biodiversity monitoring through environmental DNA (eDNA) analysis. By adopting the Maxwell RSC 48 system for automated DNA extraction, the team enhanced data quality, reduced manual contamination risks, and scaled up operations, thus improving their impact on conservation efforts. The post How The OceanOmics Centre is Using the Maxwell RSC to Scale eDNA Biodiversity Monitoring appeared first on Promega Connections.| Promega Connections
mRNA transfection offers fast, precise, non-integrating expression—perfect for sensitive cells and urgent workflows.| Promega Connections
Heart disease remains the world's top health challenge, but recent research suggests a new potential culprit: our gut microbes.| Promega Connections
See how bioluminescent assays and live-cell imaging were used to study GPCR-ligand interactions in real time.| Promega Connections
A new microfluidic organoid system could revolutionize how we personalize treatment for breast cancer patients.| Promega Connections
Learn how a computation method can predict SARS-CoV-2 variants before they emerge and help us assess vaccine efficacy to prepare for a future pandemic.| Promega Connections
This blog was written in collaboration with Tian Yang, Associate Product Manager at Promega. Cancer is often driven not only by genetic mutations, but by changes in how genes are turned on or off—epigenetic alterations. Two key players in this space are bromodomain and extra-terminal (BET) proteins and histone deacetylases (HDACs). BET proteins help activate […]| Promega Connections
This guest blog post is written by Tian Yang, Associate Product Manager at Promega. There are often challenges with translating results from a test tube into a living system, demanding more physiologically relevant assays. In drug discovery, demonstrating a compound’s ability to modulate its target protein in live cells is a critical step in the […]| Promega Connections
The weather is warming up (at least in the Northern Hemisphere). There is nothing more refreshing on a hot summer day than a dip in cool lake waters, so people everywhere are digging out their swimsuits and hitting the beach. Unfortunately, the same warm temperatures that drive us to the beach can also cause a […]| Promega Connections
With thousands of orders leaving the warehouse every week, Promega Logistics leverage teamwork and technology to meet customer expectations.| Promega Connections
Explore Wnt/β-catenin signaling, its disease relevance, and how live-cell imaging with luminescent assays supports functional studies.| Promega Connections
Three Promega employees share examples of how AI is helping them improve their work in ways that weren't possible before.| Promega Connections
In the genomics era, the promise of precision medicine and tailored diagnostics is only as good as the datasets, which makes it imperative that those sets reflect the diversity of the human population. Populations from the African continent, the most genomically diverse region in the world, are underrepresented in current genomic data sets. Nowhere is […]| Promega Connections
Discover how far-red chemigenetic biosensors enable super-resolution, multiplexed imaging of kinase activity in live cells.| Promega Connections
Measles is associated with suppression of the immune system, which makes the host vulnerable to other infections even years after recovery.| Promega Connections
Elephants may use name-like vocalizations to identify each other, highlighting their complex cognition and communication skills.| Promega Connections
Recent research reveals that starfish anatomy is even stranger than previously thoughtMost animals in the world are what biologists refer to as “bilateral”—their left and right sides mirror one another. It is also typically easy to tell which part of most animals is the top and which is the bottom. The anatomical arrangements of certain other animals, however, are slightly more confounding, for instance in the case of echinoderms, which include sea urchins, sand dollars and starfish. Th...| Promega Connections
To study whether Hmga1 could drive regeneration in mammals, researchers conducted targeted experiments in zebrafish and mice.| Promega Connections
In the permafrost of Siberia, a discovery of a mummified juvenile sabretooth (Homotherium) cat has been made, frozen for over 35,000 years.| Promega Connections
Facing challenges with metabolic-based assays in cell proliferation studies? Discover how Promega's Lumit® hKi-67 Immunoassay can help.| Promega Connections
Learn about our current understanding of malate production, its role in metabolism, and its implications in various disease states.| Promega Connections
Promega is committed to driving sustainability in life sciences through innovative products, renewable energy, and minimizing waste.| Promega Connections
How avian influenza crosses species to infect mammals has long baffled scientists. A new study may be able to help prevent future pandemics.| Promega Connections
The Promega logistics network is built to ensure you get the products you need delivered to your lab right when you need them.| Promega Connections
On our Madison campus, controlled prairie burns help prevent wildfires, control invasive species, and stimulate new growth.| Promega Connections
A new computational screening system using AI could lead to more efficient, cost-effective and expansive search for novel therapeutic drugs.| Promega Connections
Xylella fastidiosa is a plant pathogen that has devastated crops around the world, including olive groves, grapevines and citrus trees.| Promega Connections
New "nanovials" can be used to measure protein secretion, track transcriptome data, and identify relevant surface markers in a single cell.| Promega Connections
