An Unexpected Culprit in Heart Disease? Meet Your Gut Microbes - Promega Connections
Heart disease remains the world's top health challenge, but recent research suggests a new potential culprit: our gut microbes.| Promega Connections
The blog highlights the contributions of the Minderoo OceanOmics Centre to marine biodiversity monitoring through environmental DNA (eDNA) analysis. By adopting the Maxwell RSC 48 system for automated DNA extraction, the team enhanced data quality, reduced manual contamination risks, and scaled up operations, thus improving their impact on conservation efforts. The post How The OceanOmics Centre is Using the Maxwell RSC to Scale eDNA Biodiversity Monitoring appeared first on Promega Connections.| Promega Connections
Targeted protein degradation (TPD) is a strategy used to selectively remove proteins from cells, rather than simply blocking their activity. Traditional small-molecule drugs work by binding to a protein and inhibiting its function, leaving the protein intact. In contrast, TPD harnesses the cell waste-disposal system—in particular, the ubiquitin-proteasome pathway—to tag the target protein for destruction. […] The post How Thalidomide and Molecular Glues Are Redefining Drug Discovery ap...| Promega Connections
This guest blog post is written by Tian Yang, Associate Product Manager at Promega. In the realm of chemical probe development and drug discovery, understanding the interactions between drugs/compounds and their targets is crucial. Two frequently used metrics to characterize these interactions are IC50 and Kd, which guide researchers in evaluating the potential of compounds […] The post Exploring the Relationship Between IC50 and Kd in Pharmacology appeared first on Promega Connections.| Promega Connections
Transfection is a core technique in molecular biology used to introduce foreign nucleic acids—such as DNA, RNA, or small RNAs like siRNA, shRNA, and miRNA—into eukaryotic cells. This enables researchers to manipulate gene expression and study cellular processes, disease mechanisms and therapeutic strategies (1). Advances in transfection technology now support a range of nucleic acid […] The post Why mRNA Transfection Is Transforming Transient Expression Workflows appeared first on Prome...| Promega Connections
Heart disease remains the world's top health challenge, but recent research suggests a new potential culprit: our gut microbes.| Promega Connections
This blog was written by guest author Michael Curtin, Senior Product Manager, Small Molecule Drug Discovery. ATP is the universal energy currency of cells, and thousands of proteins outside the kinase family “spend” it to move cargo, remodel nucleic acids, pump ions, or fold proteins. These ATP-hydrolyzing enzymes—collectively known as ATPases—span functional classes including motor […] The post ATP-Powered Proteins Beyond Kinases – and Why Helicases Are Stealing the Spotlight app...| Promega Connections
Luciferase reporter assays are highly versatile, but their true power comes when the reporter system you’ve selected is well aligned with your experimental objectives. Whether you’re tracking transcriptional changes or pathway activity, assessing miRNA/siRNA regulation, or using as a readout in CRISPR-based screens, choosing a reporter and detection assay format that fit your specific research […] The post Matching Luciferase Reporter Assays to Your Experimental Goals appeared first on ...| Promega Connections
See how bioluminescent assays and live-cell imaging were used to study GPCR-ligand interactions in real time.| Promega Connections
A new microfluidic organoid system could revolutionize how we personalize treatment for breast cancer patients.| Promega Connections
As SARS-CoV-2 continues to evolve, one lesson is painfully clear: immunity today may not guarantee protection tomorrow. Viruses are experts at mutating into countless variants to evade detection or neutralization by the immune system. In the race to keep up with this “immune escape”, researchers have largely focused on reactive strategies—testing vaccines against variants that […] The post How Computational Design Can Predict the Next Viral Variant—and Help Us Prepare appeared first...| Promega Connections
For twenty years, the transplant lab at Dialysis Clinic, Inc. (DCi) in Nashville, TN has depended on Maxwell instruments for their automated nucleic acid purification. In fact, the lab was the first to purchase the instrument when it debuted in 2005. Today, they’ve scaled up to three of the latest Maxwell® Instruments. “They’re great little […] The post 20 Years of Organ Transplant Testing with Maxwell® Instrumentation appeared first on Promega Connections.| Promega Connections
This blog was written in collaboration with Tian Yang, Associate Product Manager at Promega. Cancer is often driven not only by genetic mutations, but by changes in how genes are turned on or off—epigenetic alterations. Two key players in this space are bromodomain and extra-terminal (BET) proteins and histone deacetylases (HDACs). BET proteins help activate […]| Promega Connections
This guest blog post is written by Tian Yang, Associate Product Manager at Promega. There are often challenges with translating results from a test tube into a living system, demanding more physiologically relevant assays. In drug discovery, demonstrating a compound’s ability to modulate its target protein in live cells is a critical step in the […]| Promega Connections
The weather is warming up (at least in the Northern Hemisphere). There is nothing more refreshing on a hot summer day than a dip in cool lake waters, so people everywhere are digging out their swimsuits and hitting the beach. Unfortunately, the same warm temperatures that drive us to the beach can also cause a […]| Promega Connections
Scientists monitor the brain activity of black-capped chickadees while they stashed and retrieved seeds to learn more about episodic memory.| Promega Connections
Key insights into the genetic patterning of starfish anatomy leads scientists to believe that a starfish is mostly just a head.| Promega Connections
With thousands of orders leaving the warehouse every week, Promega Logistics leverage teamwork and technology to meet customer expectations.| Promega Connections
Explore Wnt/β-catenin signaling, its disease relevance, and how live-cell imaging with luminescent assays supports functional studies.| Promega Connections
Three Promega employees share examples of how AI is helping them improve their work in ways that weren't possible before.| Promega Connections
In the genomics era, the promise of precision medicine and tailored diagnostics is only as good as the datasets, which makes it imperative that those sets reflect the diversity of the human population. Populations from the African continent, the most genomically diverse region in the world, are underrepresented in current genomic data sets. Nowhere is […]| Promega Connections
Discover how far-red chemigenetic biosensors enable super-resolution, multiplexed imaging of kinase activity in live cells.| Promega Connections
Thoughts, tech tips and news about science| Promega Connections
Measles is associated with suppression of the immune system, which makes the host vulnerable to other infections even years after recovery.| Promega Connections
Elephants may use name-like vocalizations to identify each other, highlighting their complex cognition and communication skills.| Promega Connections
Recent research reveals that starfish anatomy is even stranger than previously thoughtMost animals in the world are what biologists refer to as “bilateral”—their left and right sides mirror one another. It is also typically easy to tell which part of most animals is the top and which is the bottom. The anatomical arrangements of certain other animals, however, are slightly more confounding, for instance in the case of echinoderms, which include sea urchins, sand dollars and starfish. Th...| Promega Connections
To study whether Hmga1 could drive regeneration in mammals, researchers conducted targeted experiments in zebrafish and mice.| Promega Connections
In the permafrost of Siberia, a discovery of a mummified juvenile sabretooth (Homotherium) cat has been made, frozen for over 35,000 years.| Promega Connections
Tess (left) and Evie (right) spent the summer after high school graduation interning in Promega R&D.| Promega Connections
Facing challenges with metabolic-based assays in cell proliferation studies? Discover how Promega's Lumit® hKi-67 Immunoassay can help.| Promega Connections
Learn about our current understanding of malate production, its role in metabolism, and its implications in various disease states.| Promega Connections
Promega is committed to driving sustainability in life sciences through innovative products, renewable energy, and minimizing waste.| Promega Connections
How avian influenza crosses species to infect mammals has long baffled scientists. A new study may be able to help prevent future pandemics.| Promega Connections
The Promega logistics network is built to ensure you get the products you need delivered to your lab right when you need them.| Promega Connections
On our Madison campus, controlled prairie burns help prevent wildfires, control invasive species, and stimulate new growth.| Promega Connections
A new computational screening system using AI could lead to more efficient, cost-effective and expansive search for novel therapeutic drugs.| Promega Connections
Xylella fastidiosa is a plant pathogen that has devastated crops around the world, including olive groves, grapevines and citrus trees.| Promega Connections
New "nanovials" can be used to measure protein secretion, track transcriptome data, and identify relevant surface markers in a single cell.| Promega Connections
