Real-World Urinary Management and Outcomes in Cloacal Exstrophy Among Children and Adults
Most (94%) older children and adults with cloacal exstrophy are managed by incontinent diversion or clean intermittent catheterization.| Pediatrics Nationwide
By the Book: Guiding Teens Through Inpatient Psychiatric Stays| pediatricsnationwide.org
Most (94%) older children and adults with cloacal exstrophy are managed by incontinent diversion or clean intermittent catheterization.| Pediatrics Nationwide
Opportunities to Reduce Stress for Parents of Kids With Autism| pediatricsnationwide.org
An innovative method that uses a zebrafish model to rapidly study novel fusion-oncogenes in vivo has been developed by investigators at Nationwide Children’s Hospital.| Pediatrics Nationwide
Researchers published the first comprehensive, 3D analysis of the complete rhabdomyosarcoma genome.| Pediatrics Nationwide
Dynamic Contrast-Enhanced Ultrasound Shows Promise for Diagnosing Renal Obstruction| pediatricsnationwide.org
Feasibility study demonstrates DCEUS may be a safer, more accessible alternative to nuclear medicine. In a recent study, Bryan S. Sack, MD, chief of Pediatric Urology at Nationwide Children’s Hospital – Toledo, and colleagues demonstrated the potential of dynamic contrast-enhanced ultrasound (DCEUS) to diagnose ureteropelvic junction obstruction or blockages where the kidney connects to the […]| Pediatrics Nationwide
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Children with sickle cell disease and the Duffy null phenotype may have lower measured neutrophil counts, but new research suggests that there are opportunities to optimize hydroxyurea regardless of Duffy null status. Sickle cell disease (SCD) primarily affects individuals of minority populations and can cause numerous morbidities, including vaso-occlusive pain, acute chest syndrome episodes, and […]| Pediatrics Nationwide
A retrospective analysis of the clinical correlation between gastric emptying scintigraphy and antroduodenal manometry in pediatric patients with upper GI symptoms. Children with persistent nausea, vomiting or abdominal pain often undergo extensive testing to evaluate for underlying etiologies such as pediatric intestinal pseudo-obstruction, rumination or gastroparesis. Two primary diagnostic tools, gastric emptying scintigraphy (GES) and […]| Pediatrics Nationwide
A new model accurately identifies neonates at risk of acute kidney injury (AKI) — and the factors physicians should address to prevent it — offering the first AKI prediction tool specific to this vulnerable population. | Pediatrics Nationwide
Introducing Nationwide Children’s Hospital’s Behavioral Health Learning Library| pediatricsnationwide.org
Allison Bradbury, MS, PhD, is a principal investigator in the Center for Gene Therapy at Nationwide Children’s Hospital and an assistant professor in the Department of Pediatrics at The Ohio State University. She recently received her first R01 grant to develop novel therapeutic strategies for tubulin folding cofactor D (TBCD)-related developmental and epileptic encephalopathy. This is a multi-PI R01 with Mark Hester, PhD, a principal investigator in the Institute of Genomic Medicine. Rolf ...| Pediatrics Nationwide
Making Cell Magic| Pediatrics Nationwide
First In Human| pediatricsnationwide.org
Researchers Create Public Database of Nearly 40,000 Control Samples for Genetic Association Studies| pediatricsnationwide.org
Studying the Clinical Progression of Congenital Hypopituitarism| pediatricsnationwide.org
Hip Ultrasound Has Clinical Utility in Detecting Developmental Dysplasia of the Hip Among Preterm Infants| pediatricsnationwide.org
New research reveals the clinical progression and evolution of pituitary hormone deficiencies in the first 3 years of life. In a recent retrospective study published in Clinical Endocrinology, Jennifer M. Ladd, MD, MSc, pediatric physician in the Division of Endocrinology and associate program director of the Endocrinology Fellowship Program at Nationwide Children’s Hospital, and colleagues […]| Pediatrics Nationwide
While tracheostomy can be lifesaving for infants with severe bronchopulmonary dysplasia, new data highlights the risks and outcomes that families and providers must be prepared to face. Infants with bronchopulmonary dysplasia (BPD), the most common morbidity of prematurity, often require long-term respiratory support. Severe BPD can necessitate tracheostomy that is often paired with mechanical ventilation, […]| Pediatrics Nationwide
A positive first hip ultrasound (HUS) is highly predictive of having developmental dysplasia of the hip (DDH) among preterm infants, according to results of a study published in the American Journal of Perinatology. “In term babies, more is known about the accuracy of ultrasounds for congenital or developmental hip dysplasia. But in preterm babies, there […]| Pediatrics Nationwide
In their recent publication, Boosting Autism Screening and Referrals with EHR-Integrated Tools at Well-Child Visits, Elizabeth W. Barnhardt, DO, MAEd, developmental-behavioral pediatrician at Nationwide Children’s Hospital and faculty member at The Ohio State University College of Medicine, and her team describe a quality improvement initiative designed to improve the early identification of autism spectrum disorder […]| Pediatrics Nationwide
Pilot study supports the use of sleep questionnaires to identify underrecognized symptoms in children and adults with DM1.| Pediatrics Nationwide
A pilot study shows promise in enhancing shared decision-making and patient satisfaction through family-centered support. | Pediatrics Nationwide
Synergy is an important part of scientific endeavors, and people, teams and organizations who can harness the energy of ideas and passion for the work can leverage it to move their fields forward.| Pediatrics Nationwide
Findings highlight critical disparities and opportunities to improve care. | Pediatrics Nationwide
Bioinformatics combines the natural sciences and information technology. This rapidly developing field has become an essential piece of genomic medicine, which is currently experiencing unprecedented scientific progress in understanding inherited susceptibilities for many diseases – identification of disease risk genes, pathways and affected cell types.| Pediatrics Nationwide
Why did you decide to pursue a career in medicine, and what was your path to your current role?| Pediatrics Nationwide
6 Key Insights for Understanding Pediatric Pulmonary Hypertension| pediatricsnationwide.org
Featured Researcher – Ryan Roberts, MD, PhD| pediatricsnationwide.org
Not all genetic diseases are inherited; however, they are all the result of DNA mutations or flaws. Genetic research and gene therapy are integral in finding cures or helpful treatments for diseases such as muscular dystrophy. At the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital, research scientists are engaged in precedent-setting transitional gene therapy for the betterment of children with rare genetic and neuromuscular degenerative diseases.| Pediatrics Nationwide
Nationwide Children’s is the first pediatric hospital to implement Caring Contacts approach within its Zero Suicide initiative. The initial study period shows high enrollment and satisfaction with the program. | Pediatrics Nationwide
Researchers finally have high-quality data about the trajectory of continence outcomes — and key predictors for quality of life — across childhood for children with anorectal malformations.| Pediatrics Nationwide
Ryan D. Roberts, MD, PhD, is a physician in the Division of Hematology and Oncology at Nationwide Children’s Hospital and a principal investigator for the Center for Childhood Cancer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. He is a member of the Translational Therapeutics research program at The James Comprehensive Cancer Center at The Ohio State University and a fierce champion for childhood cancer research.| Pediatrics Nationwide
A groundbreaking study reveals how a low-risk intervention dramatically improves quality of life. | Pediatrics Nationwide
Congenital Hypothyroidism: What Endocrinologists Need to Know| pediatricsnationwide.org
New Trial Aims to Boost Kids’ Immune Systems to Fight Neuroblastoma| pediatricsnationwide.org
A new cellular therapy approach could improve outcomes and ease the treatment burden for patients and families.| Pediatrics Nationwide
New study shows essential role of RNA methlytransferase-mediated m6A modification in regulating heart development.| Pediatrics Nationwide
A subset of patients with high-risk neuroblastoma (NBL) and primary adrenal tumors develop an adrenal insufficiency (AI)-like phenotype during treatment.| Pediatrics Nationwide
A 15-year review of indications, approaches and outcomes| Pediatrics Nationwide
A new patient guidebook provides evidence-based resources to engage adolescents in their recovery throughout and after their hospital stay.| Pediatrics Nationwide
What happens when a passion for law and social advocacy intersects with science and mentorship? The result is a remarkable research scientist driven to improve pediatric health equity and access, eager to lead the next generation of scientists.| Pediatrics Nationwide
Research offers promising solutions for urinary tract infection treatment and antibiotic resistance. | Pediatrics Nationwide
Genetic variants in CR1 have significantly different population-specific frequencies and are linked with focal segmental glomerulosclerosis (FSGS) – the leading cause of nephrotic syndrome.| Pediatrics Nationwide
Suicide is the second leading cause of death for youth aged 10 to 24 in the United States, and rates have been steadily rising across the country since 2007. Since the COVID-19 pandemic, the issue has received more attention nationally. Now, a regional collaborative in central Ohio is working to reduce pediatric suicide rates by 25% by 2030.| Pediatrics Nationwide
A new study reveals that depressive symptoms, not diabetes-specific stress, forecast long-term glycemic outcomes in adolescents with type 1 diabetes. | Pediatrics Nationwide
New AAV proviral plasmid for vector manufacturing has potential to increase patient safety and make gene therapies more affordable, researchers say.| Pediatrics Nationwide
Alaina Doklovic is a Marketing Specialist for Research Communications at Nationwide Children’s Hospital. She received her BS in medical anthropology and English from The Ohio State University. Her passions for science and health, combined with her desire to help others, motivated her to pursue a career in which she could actively help improve patient outcomes and scientific research through writing.| pediatricsnationwide.org
Rolf Stottmann, PhD, is a principal investigator in the Institute for Genomic Medicine at Nationwide Children’s Hospital and professor at The Ohio State University College of Medicine. He joined Nationwide Children’s in 2021.| Pediatrics Nationwide
New therapies, from virus-mediated gene therapy to CRISPR-based treatments, are poised to change the clinical landscape of blood disorder treatments and outcomes.| Pediatrics Nationwide
Amrik Khalsa, MD, is a physician and principal investigator in the Center for Child Health Equity and Outcomes Research (CCHEOR) in the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital. He is dual medically trained and board certified in Internal Medicine and Pediatrics and has research expertise in observational research design, community-engaged research, and intergenerational obesity prevention. His research focuses on reducing disparities and improving outcomes...| Pediatrics Nationwide
During her 20-week ultrasound appointment, Brittany Badenhop learned her baby had spina bifida, a term used to describe many disorders that occur during the development of the central nervous system. Spina bifida occurs very early on in a pregnancy as the embryo forms.| Pediatrics Nationwide
If the CORD-CHD Study meets even a single endpoint, it will represent one of the simplest and most accessible improvements in congenital heart disease management in recent history.| Pediatrics Nationwide
Youth suicide is a leading cause of death in the United States. Most youth who die by suicide have no mental illness diagnosis and have visited a health care provider within a year prior to their death. In fact, 40% of those youth visited a health care provider within one month prior. | Pediatrics Nationwide
Cellular trajectories deviate early in hypoplastic left heart syndrome (HLHS) and hypoplastic right heart syndrome (HRHS) development.| Pediatrics Nationwide
The best language learners on the planet are children — especially babies. Your brain is most active in creating the language center of your brain, connecting neurons and creating the highways and pathways for processing language, during infancy. In fact, language learning begins in utero. The developing brain of a fetus starts to wire language circuitry around the speech sounds and rhythms of its mother’s voice. This process accelerates when a baby is born.| Pediatrics Nationwide
Retroperitoneal lymph node dissection (RPLND) has been a crucial component of treating testicular and paratesticular cancers for over a century. Recent advancements in minimally invasive techniques, such as robotic-assisted methods, have expanded the applicability of RPLND, offering reduced morbidity and faster recovery. However, concerns persist regarding the equivalence of oncological outcomes compared to traditional open surgery.| Pediatrics Nationwide
Lauren Dembeck, PhD, is a freelance science and medical writer based in New York City. She completed her BS in biology and BA in foreign languages at West Virginia University. Dr. Dembeck studied the genetic basis of natural variation in complex traits for her doctorate in genetics at North Carolina State University. She then conducted postdoctoral research on the formation and regulation of neuronal circuits at the Okinawa Institute of Science and Technology in Japan.| pediatricsnationwide.org
Lauren Dembeck, PhD, is a freelance science and medical writer based in New York City. She completed her BS in biology and BA in foreign languages at West Virginia University. Dr. Dembeck studied the genetic basis of natural variation in complex traits for her doctorate in genetics at North Carolina State University. She then conducted postdoctoral research on the formation and regulation of neuronal circuits at the Okinawa Institute of Science and Technology in Japan.| Pediatrics Nationwide
Lauren Dembeck, PhD, is a freelance science and medical writer based in New York City. She completed her BS in biology and BA in foreign languages at West Virginia University. Dr. Dembeck studied the genetic basis of natural variation in complex traits for her doctorate in genetics at North Carolina State University. She then conducted postdoctoral research on the formation and regulation of neuronal circuits at the Okinawa Institute of Science and Technology in Japan.| Pediatrics Nationwide
Lauren Dembeck, PhD, is a freelance science and medical writer based in New York City. She completed her BS in biology and BA in foreign languages at West Virginia University. Dr. Dembeck studied the genetic basis of natural variation in complex traits for her doctorate in genetics at North Carolina State University. She then conducted postdoctoral research on the formation and regulation of neuronal circuits at the Okinawa Institute of Science and Technology in Japan.| Pediatrics Nationwide
A new study offers insights in the complex interplay among negative emotionality, internalizing problems and parental responsivity in very young children.| Pediatrics Nationwide
You might have heard the phrase “post-truth world” used to describe the shifting dynamics of fact, fiction and trusted sources.| Pediatrics Nationwide
In the field of single-ventricle heart disease (SVHD), there are more questions than answers.| Pediatrics Nationwide
A Personalized Approach to Procedures| Pediatrics Nationwide
Study results highlight the importance of primary care in infant and maternal support. In a recent study published in Academic Pediatrics, researchers found a link between postpartum depression in mothers and the infants’ use of acute care, which includes emergency department or urgent care visits.| Pediatrics Nationwide
Without genomic sequencing, many genetic diseases would never be diagnosed.| Pediatrics Nationwide
The move from a research-first approach to genomic testing to offer more clinically available assays was driven in part by limitations in current clinical testing offerings, as well as by the decreasing cost and turn-around time of genomic sequencing. This environment drove the development of translational protocols.| Pediatrics Nationwide
Despite benefits, new study finds low rates of breastfeeding among preterm infants discharged from the NICU. Mother’s own milk (MOM) and direct breastfeeding (DBF) are associated with numerous health and development advantages, especially for preterm infants. However, the rates of MOM feeding and DBF among infants admitted to neonatal intensive care units (NICUs) are low, says Sudarshan Jadcherla, MD, a principal investigator at the Center for Perinatal Research and medical director of the ...| Pediatrics Nationwide
Despite the improvements in scale and speed of generating genomic sequencing data, the challenge of genomic analysis and its costs remains.| Pediatrics Nationwide
Researchers from Nationwide Children’s Hospital and The Ohio State University are focusing on how early exposures might be associated with areas such as neurodevelopment and cardiovascular outcomes as part of a large national study, Environmental influences on Child Health Outcomes (ECHO) Program.| Pediatrics Nationwide
Recent survey reveals a mismatch in career expectations and realities, calling for enhanced mentorship and policy reform.| Pediatrics Nationwide
After over a decade in Neonatology at Nationwide Children’s Hospital, Dr. Schlegel has been appointed section chief of Neonatology. We recently sat down to talk with Dr. Schlegel about her time at Nationwide Children’s and her plans for leading the next phase of growth in Neonatal care.| Pediatrics Nationwide
As a long-time pediatric trauma clinician-scientist, Julie Leonard, MD, MPH, board-certified emergency medicine specialist and principal investigator in the Center for Injury Research and Policy at Nationwide Children’s Hospital, has contributed to numerous veins of research in her field. The recent publication of a set of clinical prediction criteria for cervical spine injury represents the culmination of more than two decades of hard work and, she says, the most significant achievement of...| Pediatrics Nationwide
A new study reinforces the importance of sleep for concussion recovery and supports recommendations for quality nighttime sleep with limited naps. | Pediatrics Nationwide
Focusing on non-pharmacological care, emphasizing mother-baby bonding, and natural infant behaviors may keep infants out of the NICU, but other barriers may limit implementation.| Pediatrics Nationwide
Thorough management guidelines for babies born before 27 weeks’ gestation join the program’s long list of accomplishments in improving survival and standardizing care for this vulnerable population.| Pediatrics Nationwide
Nationwide Children’s researchers develop a scalable, targeted approach to overcoming cancer’s toughest challenges.| Pediatrics Nationwide
An interview with Allen A. Kadado, MD, director of the Nationwide Children’s Hospital Center for Orthopedic Innovation, director of the Nationwide Children’s Pediatric Orthopedic Residency Program| Pediatrics Nationwide
How a new approach to correcting heterozygous mutations and other novel techniques for gene editing are transforming the potential to combat disease| Pediatrics Nationwide
Highchairs are common in homes with babies and toddlers, as well as in places such as hospitals and restaurants where young children are fed. In hospitals, they are mainly used in pediatric care for infants, toddlers and children undergoing treatment or recovery. Highchairs provide a safe, stable seating option during meals and interactions with family, friends and staff, promoting normalcy and supporting developmental needs.| Pediatrics Nationwide
Kidney stones in children are on the rise, and many of these children miss critical post-op follow-ups. What prevents them from returning, and how can we help?| Pediatrics Nationwide
Condition| Pediatrics Nationwide
A new umbrella trial of molecularly driven therapies for high-grade gliomas (HGG) and diffuse intrinsic pontine glioma (DIPG) aims to improve quality of live and extend survival rates for these aggressive tumors.| Pediatrics Nationwide
Investigators from Nationwide Children’s Hospital created fratricide-resistant and metabolically-enhanced chimeric antigen receptor (CAR) natural killer (NK) and T cells that have cytotoxic effects on many hematologic tumors.| Pediatrics Nationwide
Phase 3 Trial at Nationwide Children’s Supports Safety and Efficacy in Children Aged 6–17.| Pediatrics Nationwide
Q: How Do GLP-1 Receptor Agonists Work in Pediatric Diabetes Care?| Pediatrics Nationwide
A Parent Council in an ongoing pediatric stroke rehabilitation trial provides important insights into how parent involvement can inform and enrich the research process.| Pediatrics Nationwide
Jessica Nye, PhD, is a freelance science and medical writer based in Barcelona, Spain. She completed her BS in biology and chemistry and MS in evolutionary biology at Florida State University. Dr. Nye studied population genetics for her doctorate in biomedicine at University of Pompeu Fabra. She conducted her postdoctoral research on the inheritance of complex traits at the Autonomous University of Barcelona.| pediatricsnationwide.org
Lung transplantation (LTx) for cystic fibrosis (CF) may trigger bidirectional, long-distance migration of tissue specific stem cells (TSC), causing a chimeric phenotype which could have implications for host defense capabilities.| Pediatrics Nationwide
A deep classification of epigenetic machinery in rhabdomyosarcoma (RMS) tumors finds that the mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) complexes are essential for the stabilization of RMS.| Pediatrics Nationwide
Researchers conduct a molecular comparison between the established EWS/FLI translocation with rarer FET/ETS fusions, broadly supporting the inclusion of FET/ETS chimeric proteins in Ewing Sarcoma diagnosis and treatment.| Pediatrics Nationwide
Leveraging Technology and Partnerships to Transform Pediatric Orthopedic Care| pediatricsnationwide.org
What Are the Mission and Vision of the MPDC?| Pediatrics Nationwide
Structured data entry not only reduces the amount of time physicians are spending in the electronic health record but also opens the door for new research.| Pediatrics Nationwide
A new position paper offers recommendations for the evaluation and management of iron deficiency in children undergoing intestinal rehabilitation.| Pediatrics Nationwide
Researchers investigate disparities in selective dorsal rhizotomy (SDR) access and follow-up care. | Pediatrics Nationwide
Medications for opioid use disorder (MOUD) is the recommended first line treatment for adolescents with opioid use disorder (OUD), the chronic use of opioids and/or synthetic opioids that causes clinically significant distress or impairment.| Pediatrics Nationwide
