The story of CGA-IGC begins in 1995, when James Church suggested that clinicians and researchers in the US who were interested in...| Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
Last week, we featured short video snippets from three individuals living with a hereditary GI cancer syndrome, each sharing their...| Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
During the 2025 Hereditary Cancer Awareness Week , we are especially honored to amplify the patient voice by sharing powerful, personal...| Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
Lynch syndrome (LS), driven by germline pathogenic variants in the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, PMS2, and EPCAM deletions), is classically associated with MMR-deficient (MMR-D) or microsatellite instability–high (MSI-H) colorectal cancer (CRC). These tumors carry prognostic and therapeutic significance: improved outcomes relative to microsatellite stable disease, lack of benefit from fluorouracil-based adjuvant chemotherapy, and strong predictive value for response t...| CGA-IGC
The Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) was established in 1995 to improve understanding of the basic science of inherited colorectal cancer and the clinical management of affected families.| CGA-IGC
Hereditary diffuse gastric cancer (HDGC) has long been recognized as one of the most penetrant hereditary cancer syndromes, primarily linked to pathogenic variants in the CDH1 gene. Early reports painted a sobering picture, with lifetime gastric cancer risks estimated at over 80%, often leading to prophylactic total gastrectomy as the “default” recommendation. But in recent years, the story of CDH1 has shifted. New penetrance data, updated guideline recommendations, and a growing understa...| CGA-IGC
Our latest webinar featured a thought-provoking presentation by Jennifer K. Wagner, JD, PhD, Assistant Professor of Law, Policy and Engineering and Anthropology, exploring the legal, ethical, and practical complexities of recontacting patients after changes in clinical guidelines. This is an increasingly important topic at the intersection of law and the rapidly evolving field of genomic medicine.One of the core themes of this episode was the distinction between research and clinical care, inclu| CGA-IGC
Ophir Gilad, MD - CGA-IGC Communications Committee Member If you missed our Research Committee Webinar or would like to revisit the...| Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
Zachariah H. Foda, MD, PhD, CGA-IGC Communications Committee Member In the latest episode of the CGA-IGC Podcast Series 2025 , host...| Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
Check here for collections of authoritative multi-media resources on a variety of topics that will help advance care of hereditary gastrointestinal cancer patients.| CGA-IGC
Rita Matos, PhD - CGA-IGC Communications CommitteeIn our most recent CGA IGC webinar session, "How We Do It: Care of AYAs," we explored the best practices for managing care in adolescents and young adults (AYA) with cancer predisposition syndromes. We were joined by three outstanding professionals: Stacy Hines-Dowell, DNP, FNP-BC, AGN-BC, ACGN; Melissa Perrino, MD; and Rose McGee, MS, CGC.Together, they provided valuable guidance and shared real-world examples to support a smooth, patient-ce...| CGA-IGC
Chandrika Kurpad, MS, LCGC - Communications Committee member A study published in the Journal of Genetic Counseling sheds light on why...| Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
Alessandro Mannucci, MD, CGA-IGC Communications Committee MemberIn the final episode of our research collaboration podcast series, CGA-IGC's Emma Keel, a genetic counselor at the University of Chicago, sits down with Melyssa Aronson and Lucie Stengs from Toronto’s Hospital for Sick Children to discuss the evolution and global impact of the International Replication Repair Deficiency Consortium (IRRDC)—a major collaborative effort to understand and manage constitutional mismatch repair de...| CGA-IGC
Zachariah H Foda, MD, PhD - CGA-IGC Communications Committee MemberIn this second episode of the CGA-IGC Research Collaboration Podcast Series, hosted by Emma Keel, MS, CGC and featuring Ophir Gilad, MD, a research fellow at the University of Chicago, shares the compelling journey behind the creation of the GASTRIC (Group of investigAtors STriving toward Research In CDH1) multicenter consortium, a groundbreaking initiative addressing critical knowledge gaps in CDH1-related gastric cancer.Dr....| CGA-IGC
If you missed the second webinar in our 2025 series or would like to revisit the discussion, the recording is now available on-demand for current CGA-IGC members (you must login to the member portal). Not yet a member? Learn more about joining HERE.In this joint session with NASPGHAN, Isabel C. Rojas, MD from UT Southwestern Medical Center delivered an in-depth presentation on endoscopic surveillance in Peutz-Jeghers Syndrome.Dr. Rojas opened with an overview of the genetics, diagnostic criteria| CGA-IGC
Alessandro Mannucci, MD, CGA-IGC Communications Committee MemberIn this first episode of the CGA-IGC Research Collaboration Podcast Series, Dr. Joshua Melson, a gastroenterologist at the University of Arizona Cancer Center, sits down with leading experts from the LINEAGE Consortium—a cutting-edge research collaboration tackling the complexities of Lynch Syndrome. This hereditary GI cancer syndrome affects 1 in 279 individuals yet remains vastly underdiagnosed due to its diverse presentatio...| CGA-IGC
Learn from our president , Beth Dudley Yurkovich MS, MPH, CGC, CGAF about the importance of this partnership with Fight CRC. "CGA-IGC's...| Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
The mission of CGA-IGC is to serve as a resource for its members and the wider #HereditaryGICommunity . Knowledge empowers both...| Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
Kimberly Hilfrank, Chair, CGA-IGC Communications CommitteeIn observance of National Black History Month 2025, CGA-IGC would like to celebrate the important work done by Black scientists throughout history.Georgia DunstonHailing from Norfolk, Virginia, Dr. Georgia Dunston received her PhD in Human Genetics from the University of Michigan in 1972. She was then recruited to the Howard University College of Medicine, where she helped to found the National Human Genome Center (NHGC). The mission of t| CGA-IGC
Rita Barbosa-Matos, PhD - CGA-IGC Communications CommitteeOur recent webinar featured discussions on groundbreaking studies in hereditary cancer syndromes and colorectal cancer screening, highlighting new insights into cancer prevention, early detection, and genetic risk assessment.Sanjeevani Arora, PhD, introduced a study by Bolivar AM et al. (2024), which explored the genomic landscape of colorectal neoplasia in Lynch Syndrome (LS). The research identified shared mutated neoantigens in precanc| CGA-IGC
Kimberly Hilfrank, MS, MPH, CGC (Chair)Michelle Springer, MS, CGC (Vice Chair)Megha Ranganathan, MS, CGC (2024 Chair)Communication Committee The Collaborative Group of the Americas on Inherited Gastrointestinal Cancer was excited to hold its 28th annual meeting in Philadelphia, PA, from November 14-16, 2024. The meeting marked CGA-IGC’s most highly-attended conference to date, with over 500 registered individuals from 19 different countries. A record number of 32 sponsors supported the ...| CGA-IGC
Zachariah H Foda MD, PhD - CGA-IGC Communications committee In this month's, CGA-IGC podcast episode, Dr. Pal Møller, founder of The...| Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
