In a recent preprint, we describe deep-learning breakthroughs that significantly expand the types of proteins and protein assemblies that can be modeled and designed using computers. [Update: This work was published in Science on March 7, 2024.] This work updates two of our most powerful software tools, RoseTTAFold and RFdiffusion, by training them to operate on additional types of| Baker Lab • UW Institute for Protein Design
Over the past two years, machine learning has revolutionized protein structure prediction. Now, three papers in Science describe a similar revolution in protein design. In the new papers, we show that machine learning can be used to create proteins much more accurately and quickly than previously possible. This could lead to many new vaccines, treatments,| Baker Lab • UW Institute for Protein Design
New peptide-MHC binding proteins promote targeted immune activation.| Baker Lab • UW Institute for Protein Design
Generative AI can be used to create proteins that bind disordered proteins and peptides with atomic precision.| Baker Lab • UW Institute for Protein Design
New regenerative medicine proteins called NeoNectins help biomaterials work better with the body by guiding cells to attach, grow, and heal.| Baker Lab • UW Institute for Protein Design
Postdoc Roman Barth, PhD, has received a Harold M. Weintraub Graduate Student Award. He's now building new molecular machines.| Baker Lab • UW Institute for Protein Design
Our fine-tuned AI model generates functional antibodies with atomic precision. It's also free to use.| Baker Lab • UW Institute for Protein Design
Custom catalysts may help break down plastics and synthesize medicines.| Baker Lab • UW Institute for Protein Design
AI-generated proteins that protect animals in the lab promise safer, more accessible antivenoms.| Baker Lab • UW Institute for Protein Design
Postdoc Han Raut Altae-Tran, PhD, has received a Life Sciences Research Foundation fellowship. He’s designing RNA-binding proteins to regulate key biological functions. The post Congrats Han! first appeared on Baker Lab.| Baker Lab
"We've created a new approach that uses simpler components, achieves greater precision, and can be applied to virtually any target molecule on the surface of cells." The post Targeted protein degradation through advanced protein design first appeared on Baker Lab.| Baker Lab
We've found new secondary structures by screening over 100 uncommon amino acids, unlocking fresh building blocks for molecular engineering. The post Design of noncanonical alpha helices first appeared on Baker Lab.| Baker Lab