Researchers from the University of Turin published the results of a prospective, randomized, and controlled trial evaluating the use of L-carnitine and selenium when combined with standard therapy for Graves’ disease, an autoimmune disorder that affects the thyroid gland. This study follows a previously published pilot study, which found that 500 mg of L-carnitine in combination with 83 mcg selenium (as selenomethionine) taken daily for one month could improve quality of life and symptoms a...| Biotics Research Blog
Trihalomethanes The results of a cohort study published in JAMA Network Open show the effect of trihalomethanes in community drinking water on the risk of chronic kidney disease (CKD). Trihalomethanes (THMs) are one of several unintended byproducts of chlorination, and include chloroform and three brominated compounds (bromodichloromethane, dibromochloromethane, and bromoform), with the latter more common in coastal and saltwater regions. Exposure to THMs has already been established as a r...| Biotics Research Blog
Findings from a 2023 study published in The American Journal of Physiology – Cell Physiology underscore that skeletal muscle is strongly dependent on mitochondrial integrity and the regulation of cellular senescence. This relationship becomes evident when either system is disrupted, as senescent cell accumulation can impede mitochondrial function, compromising muscle adaptability and systemic resilience.| blog.bioticsresearch.com
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The journal Alzheimer’s & Dementiapublished the results of a lipidomics study, which found significant differences in plasma lipids associated with Alzheimer’s disease (AD), but only among women. This study was a post hoc analysis of data from two cohorts, the AddNeuroMed and Dementia Case Register cohorts, both conducted among European populations. A total of 841 participants were involved, including 306 diagnosed with AD, 165 with mild cognitive impairment (MCI), and 370 cognitively hea...| Biotics Research Blog
A study published in Cell Reports Medicine examined the role of homocysteine in glaucoma development and progression, including models of glaucoma, clinical data, and Mendelian randomization, and suggests that several B vitamins have a promising role as neuroprotective agents. Homocysteine elevations have been linked to a number of neurodegenerative diseases, but it has been difficult to determine if it is a causative agent or a biomarker for other pathological processes (or nutrient deficien...| blog.bioticsresearch.com
The results of a network meta-analysis, which evaluated the use of various nutritional supplements for chronic obstructive pulmonary disease (COPD), were published in BMC Pulmonary Medicine. This analysis included 37 randomized and controlled trials, a total of nearly 2,000 participants with COPD, and 21 nutritional interventions. Network analysis allows for a rough comparison between interventions that have not necessarily been compared directly. COPD was defined in these studies as a Forced...| Biotics Research Blog
The Lancet Planetary Health has published a systematic review and meta-analysis of studies examining the association between air pollution and incident dementia. This review was intended to summarize all previous reviews, identify specific gaps in data, and incorporate new primary research. It included data from 32 studies and a pooled population of over 26 million people, evaluating the effect of long-term exposure (defined as one or more years) to single outdoor air pollutants on a subseque...| Biotics Research Blog
Depression is increasingly recognized as a complex, multisystemic condition that extends well beyond neurotransmitter imbalance. Growing evidence reveals a compelling connection between compromised detoxification pathways and the development of depressive symptoms, suggesting that reduced capacity to eliminate toxins can drive systemic inflammation, mitochondrial dysfunction and neurochemical alterations.| blog.bioticsresearch.com
Panvascular disease, or PVD, is an emerging clinical concept referring to a multisite atherosclerotic process that occurs simultaneously or sequentially, affecting multiple vascular beds (e.g., coronary, cerebral, peripheral, etc.). With this approach as its focus, the journal Lipids in Health and Disease published a review which looked at the significance of lipoprotein(a) in PVD.| blog.bioticsresearch.com
The journal Genes (Basel) has published a review of gene-diet interactions in type 2 diabetes mellitus (T2D), describing both the current understanding of genetic risk as well as potential approaches to target genetic risk with nutritional interventions. There is a clear role for hereditary risk in T2D, with first-degree relatives of people with T2D at 3-fold greater risk for developing it themselves. Yet, for most people with T2D, it is the accumulation of many genetic variants that appears ...| blog.bioticsresearch.com